New advancement in noninvasive measurement of blood glucose by near-infrared spectroscopy

Noninvasive blood glucose measurement with near-infrared spectroscopy suitable for home use would allow a more accuracy and frequent determination of glucose level, along with reducing the long-term health care costs of diabetic patients due to no reagents. The fundamental research results of noninvasive blood glucose sensing of our research group are introduced in this paper. They are involving the aspects as followed, the prediction results of the fundamental experiments by PLS calibration method and artificial neural networks respectively; the wavelength selection by genetic algorithm; the quantitative relation among prediction accuracy, instrumental precision and regression algorithms; and the determination of measuring mode according to the measuring wavelength range, and so on. The experiments that done with the samples from simple ones to complex ones have proved the feasibility of noninvasive blood glucose measurement methodology by near-infrared spectroscopy. In addition, the further research subjects of the fundamental problems involving human body measurement are proposed.