Multilevel Nanoarchitecture Exhibiting Biosensing for Cancer Diagnostics by Dual-Modal Switching of Optical and Magnetic Resonance Signals

Ruichan Lv; Miao Feng; Liyang Xiao; Jossana A. Damasco; Jie Tian; Paras N. Prasad

doi:10.1021/acsabm.8b00429

Multilevel Nanoarchitecture Exhibiting Biosensing for Cancer Diagnostics by Dual-Modal Switching of Optical and Magnetic Resonance Signals

Ruichan Lv^*
, Miao Feng
, Liyang Xiao
, Jossana A. Damasco
, Jie Tian
, Paras N. Prasad

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

In this research, the fabrication and application of a multifunctional core-shell nanoarchitecture are proposed. NaYF₄:Yb,Er@NaYF₄:Yb,Nd exhibits upconversion luminescence (UCL) of erbium ions but has quenched UCL emission when it is coated with MnO₂ nanosheets. This hierarchical multilevel UCNP-MnO₂ exhibits restoration of UCL and generation of a magnetic resonance imaging (MRI) signal when it is exposed to a microenvironment containing glutathione (GSH)/H₂O₂, which strips the MnO₂ sheets by converting them to paramagnetic Mn²⁺ ions. This dual-modal switching feature of the optical emission and MRI signals provides a platform for stimuli-responsive biosensing of GSH/H₂O₂. Our new formulation as a dual-modal biosensor for detecting aberrant levels of intracellular GSH/H₂O₂ associated in cancer cells could be a potential diagnostic probe to distinguish tumor cells from normal cells.

Original language	English
Pages (from-to)	1505-1511
Number of pages	7
Journal	ACS Applied Bio Materials
Volume	1
Issue number	5
DOIs	https://doi.org/10.1021/acsabm.8b00429
State	Published - 19 Nov 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

MRI signal
biosensing
stimuli responsive
upconversion

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10.1021/acsabm.8b00429

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title = "Multilevel Nanoarchitecture Exhibiting Biosensing for Cancer Diagnostics by Dual-Modal Switching of Optical and Magnetic Resonance Signals",

abstract = "In this research, the fabrication and application of a multifunctional core-shell nanoarchitecture are proposed. NaYF4:Yb,Er@NaYF4:Yb,Nd exhibits upconversion luminescence (UCL) of erbium ions but has quenched UCL emission when it is coated with MnO2 nanosheets. This hierarchical multilevel UCNP-MnO2 exhibits restoration of UCL and generation of a magnetic resonance imaging (MRI) signal when it is exposed to a microenvironment containing glutathione (GSH)/H2O2, which strips the MnO2 sheets by converting them to paramagnetic Mn2+ ions. This dual-modal switching feature of the optical emission and MRI signals provides a platform for stimuli-responsive biosensing of GSH/H2O2. Our new formulation as a dual-modal biosensor for detecting aberrant levels of intracellular GSH/H2O2 associated in cancer cells could be a potential diagnostic probe to distinguish tumor cells from normal cells.",

keywords = "MRI signal, biosensing, stimuli responsive, upconversion",

author = "Ruichan Lv and Miao Feng and Liyang Xiao and Damasco, \{Jossana A.\} and Jie Tian and Prasad, \{Paras N.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = nov,

day = "19",

doi = "10.1021/acsabm.8b00429",

language = "英语",

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T1 - Multilevel Nanoarchitecture Exhibiting Biosensing for Cancer Diagnostics by Dual-Modal Switching of Optical and Magnetic Resonance Signals

AU - Lv, Ruichan

AU - Feng, Miao

AU - Xiao, Liyang

AU - Damasco, Jossana A.

AU - Tian, Jie

AU - Prasad, Paras N.

PY - 2018/11/19

Y1 - 2018/11/19

N2 - In this research, the fabrication and application of a multifunctional core-shell nanoarchitecture are proposed. NaYF4:Yb,Er@NaYF4:Yb,Nd exhibits upconversion luminescence (UCL) of erbium ions but has quenched UCL emission when it is coated with MnO2 nanosheets. This hierarchical multilevel UCNP-MnO2 exhibits restoration of UCL and generation of a magnetic resonance imaging (MRI) signal when it is exposed to a microenvironment containing glutathione (GSH)/H2O2, which strips the MnO2 sheets by converting them to paramagnetic Mn2+ ions. This dual-modal switching feature of the optical emission and MRI signals provides a platform for stimuli-responsive biosensing of GSH/H2O2. Our new formulation as a dual-modal biosensor for detecting aberrant levels of intracellular GSH/H2O2 associated in cancer cells could be a potential diagnostic probe to distinguish tumor cells from normal cells.

AB - In this research, the fabrication and application of a multifunctional core-shell nanoarchitecture are proposed. NaYF4:Yb,Er@NaYF4:Yb,Nd exhibits upconversion luminescence (UCL) of erbium ions but has quenched UCL emission when it is coated with MnO2 nanosheets. This hierarchical multilevel UCNP-MnO2 exhibits restoration of UCL and generation of a magnetic resonance imaging (MRI) signal when it is exposed to a microenvironment containing glutathione (GSH)/H2O2, which strips the MnO2 sheets by converting them to paramagnetic Mn2+ ions. This dual-modal switching feature of the optical emission and MRI signals provides a platform for stimuli-responsive biosensing of GSH/H2O2. Our new formulation as a dual-modal biosensor for detecting aberrant levels of intracellular GSH/H2O2 associated in cancer cells could be a potential diagnostic probe to distinguish tumor cells from normal cells.

KW - MRI signal

KW - biosensing

KW - stimuli responsive

KW - upconversion

UR - https://www.scopus.com/pages/publications/85065781768

U2 - 10.1021/acsabm.8b00429

DO - 10.1021/acsabm.8b00429

M3 - 文章

C2 - 34996255

AN - SCOPUS:85065781768

SN - 2576-6422

VL - 1

SP - 1505

EP - 1511

JO - ACS Applied Bio Materials

JF - ACS Applied Bio Materials

IS - 5

ER -

Multilevel Nanoarchitecture Exhibiting Biosensing for Cancer Diagnostics by Dual-Modal Switching of Optical and Magnetic Resonance Signals

Abstract

UN SDGs

Keywords

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