MRI study on abnormal gray matter volume in Alzheimer's disease

Shu Yu Li; Fang Pu; Tian Zi Jiang; Ai Zhen Liu; Sheng Xie; Yin Hua Wang

MRI study on abnormal gray matter volume in Alzheimer's disease

Shu Yu Li
, Fang Pu
, Tian Zi Jiang^*
, Ai Zhen Liu
, Sheng Xie
, Yin Hua Wang

^*Corresponding author for this work

School of Biological Science and Medical Engineering

CAS - Institute of Automation
Capital Medical University
Peking University

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To find the pattern of gray matter atrophy of Alzheimer's disease (AD). Methods: Conventional MRI were performed in 19 AD patients and 20 age-and gender-matched healthy controls. Then the volumes of global and local gray matter were analyzed by optimized voxel-based morphometry. Results: Compared to the normal aging, the global gray matter volumes of AD decreased severely (P=0.0048). The local atrophy regions focused on the bilateral hippocampus, bilateral superior temporal gyrus, and bilateral thalamus (P<0.05 corrected for multiple comparisons). Conclusion: The global and local gray matter volumes of AD have markedly reduced.

Original language	English
Pages (from-to)	1162-1164
Number of pages	3
Journal	Chinese Journal of Medical Imaging Technology
Volume	22
Issue number	8
State	Published - 20 Aug 2006

Keywords

Alzheimer's disease
Gray matter
Magnetic resonance imaging
Voxel-based morphometry

Cite this

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title = "MRI study on abnormal gray matter volume in Alzheimer's disease",

abstract = "Objective: To find the pattern of gray matter atrophy of Alzheimer's disease (AD). Methods: Conventional MRI were performed in 19 AD patients and 20 age-and gender-matched healthy controls. Then the volumes of global and local gray matter were analyzed by optimized voxel-based morphometry. Results: Compared to the normal aging, the global gray matter volumes of AD decreased severely (P=0.0048). The local atrophy regions focused on the bilateral hippocampus, bilateral superior temporal gyrus, and bilateral thalamus (P<0.05 corrected for multiple comparisons). Conclusion: The global and local gray matter volumes of AD have markedly reduced.",

keywords = "Alzheimer's disease, Gray matter, Magnetic resonance imaging, Voxel-based morphometry",

author = "Li, \{Shu Yu\} and Fang Pu and Jiang, \{Tian Zi\} and Liu, \{Ai Zhen\} and Sheng Xie and Wang, \{Yin Hua\}",

year = "2006",

month = aug,

day = "20",

language = "英语",

volume = "22",

pages = "1162--1164",

journal = "Chinese Journal of Medical Imaging Technology",

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TY - JOUR

T1 - MRI study on abnormal gray matter volume in Alzheimer's disease

AU - Li, Shu Yu

AU - Pu, Fang

AU - Jiang, Tian Zi

AU - Liu, Ai Zhen

AU - Xie, Sheng

AU - Wang, Yin Hua

PY - 2006/8/20

Y1 - 2006/8/20

N2 - Objective: To find the pattern of gray matter atrophy of Alzheimer's disease (AD). Methods: Conventional MRI were performed in 19 AD patients and 20 age-and gender-matched healthy controls. Then the volumes of global and local gray matter were analyzed by optimized voxel-based morphometry. Results: Compared to the normal aging, the global gray matter volumes of AD decreased severely (P=0.0048). The local atrophy regions focused on the bilateral hippocampus, bilateral superior temporal gyrus, and bilateral thalamus (P<0.05 corrected for multiple comparisons). Conclusion: The global and local gray matter volumes of AD have markedly reduced.

AB - Objective: To find the pattern of gray matter atrophy of Alzheimer's disease (AD). Methods: Conventional MRI were performed in 19 AD patients and 20 age-and gender-matched healthy controls. Then the volumes of global and local gray matter were analyzed by optimized voxel-based morphometry. Results: Compared to the normal aging, the global gray matter volumes of AD decreased severely (P=0.0048). The local atrophy regions focused on the bilateral hippocampus, bilateral superior temporal gyrus, and bilateral thalamus (P<0.05 corrected for multiple comparisons). Conclusion: The global and local gray matter volumes of AD have markedly reduced.

KW - Alzheimer's disease

KW - Gray matter

KW - Magnetic resonance imaging

KW - Voxel-based morphometry

UR - https://www.scopus.com/pages/publications/33748422346

M3 - 文章

AN - SCOPUS:33748422346

SN - 1003-3289

VL - 22

SP - 1162

EP - 1164

JO - Chinese Journal of Medical Imaging Technology

JF - Chinese Journal of Medical Imaging Technology

IS - 8

ER -

MRI study on abnormal gray matter volume in Alzheimer's disease

Abstract

Keywords

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