Mg(II)-Catalyzed [4+2] Annulation for the Synthesis of 2-Arylquinoline Motifs: Applications and DFT Studies

Tao Yang; Yibo Qin; Yaping Wang; Fu Song; Heng Ying Xiong; Teng Wang; Guangwu Zhang

doi:10.1002/adsc.202301039

Mg(II)-Catalyzed [4+2] Annulation for the Synthesis of 2-Arylquinoline Motifs: Applications and DFT Studies

Tao Yang
, Yibo Qin
, Yaping Wang
, Fu Song
, Heng Ying Xiong^*
, Teng Wang^*
, Guangwu Zhang^*

^*Corresponding author for this work

School of Chemistry

Henan University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Mg-catalyzed [4+2] cycloaddition reactions between 2-aminobenzaldehydes and ynones offered an array of 2-arylquinoline motifs merged with a CF₃-acyl group. Furthermore, with Mg-catalyzed [4+2] annulation as the key step, DDD107498, DDD102542, and Hit analogues were assembled. Finally, a computational study of the reaction mechanism was conducted.

Original language	English
Pages (from-to)	1382-1387
Number of pages	6
Journal	Advanced Synthesis and Catalysis
Volume	366
Issue number	6
DOIs	https://doi.org/10.1002/adsc.202301039
State	Published - 19 Mar 2024

Keywords

Magnesium
Quinoline
[4+2] Annulation

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10.1002/adsc.202301039

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title = "Mg(II)-Catalyzed [4+2] Annulation for the Synthesis of 2-Arylquinoline Motifs: Applications and DFT Studies",

abstract = "Mg-catalyzed [4+2] cycloaddition reactions between 2-aminobenzaldehydes and ynones offered an array of 2-arylquinoline motifs merged with a CF3-acyl group. Furthermore, with Mg-catalyzed [4+2] annulation as the key step, DDD107498, DDD102542, and Hit analogues were assembled. Finally, a computational study of the reaction mechanism was conducted.",

keywords = "Magnesium, Quinoline, [4+2] Annulation",

author = "Tao Yang and Yibo Qin and Yaping Wang and Fu Song and Xiong, \{Heng Ying\} and Teng Wang and Guangwu Zhang",

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year = "2024",

month = mar,

day = "19",

doi = "10.1002/adsc.202301039",

language = "英语",

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TY - JOUR

T1 - Mg(II)-Catalyzed [4+2] Annulation for the Synthesis of 2-Arylquinoline Motifs

T2 - Applications and DFT Studies

AU - Yang, Tao

AU - Qin, Yibo

AU - Wang, Yaping

AU - Song, Fu

AU - Xiong, Heng Ying

AU - Wang, Teng

AU - Zhang, Guangwu

PY - 2024/3/19

Y1 - 2024/3/19

N2 - Mg-catalyzed [4+2] cycloaddition reactions between 2-aminobenzaldehydes and ynones offered an array of 2-arylquinoline motifs merged with a CF3-acyl group. Furthermore, with Mg-catalyzed [4+2] annulation as the key step, DDD107498, DDD102542, and Hit analogues were assembled. Finally, a computational study of the reaction mechanism was conducted.

AB - Mg-catalyzed [4+2] cycloaddition reactions between 2-aminobenzaldehydes and ynones offered an array of 2-arylquinoline motifs merged with a CF3-acyl group. Furthermore, with Mg-catalyzed [4+2] annulation as the key step, DDD107498, DDD102542, and Hit analogues were assembled. Finally, a computational study of the reaction mechanism was conducted.

KW - Magnesium

KW - Quinoline

KW - [4+2] Annulation

UR - https://www.scopus.com/pages/publications/85184440072

U2 - 10.1002/adsc.202301039

DO - 10.1002/adsc.202301039

M3 - 文章

AN - SCOPUS:85184440072

SN - 1615-4150

VL - 366

SP - 1382

EP - 1387

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 6

ER -

Mg(II)-Catalyzed [4+2] Annulation for the Synthesis of 2-Arylquinoline Motifs: Applications and DFT Studies

Abstract

Keywords

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