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MEG source imaging algorithm for finding deeper epileptogenic zone

  • Yegang Hu
  • , Yicong Lin
  • , Baoshan Yang
  • , Guangrui Tang
  • , Yuping Wang
  • , Jicong Zhang*
  • *Corresponding author for this work
  • Beihang University
  • Capital Medical University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In recent years, magnetoencephalography (MEG) has played a prominent role on neocortical epilepsy preoperative evaluation. However, its clinical utility with locating deeper sources may be more challenging such as the mesial temporal structures. We proposed a new source imaging algorithm for finding the epileptogenic zone in mesial temporal lobe epilepsy (mTLE). Since the localization results using the Elekta MEG method are very sensitive to some MEG noises, the source modeling was modified by spatial filtering in wavelet domain and cortex constraint. Two surgical patients randomly selected with medically refractory mTLE, which were diagnosed based on a comprehensive preoperative evaluation, had been studied in this manuscript. The localization results using proposed method on individual MRI showed that the deeper regions had been exactly found in the mesial temporal lobe. Yet, the results using the Elekta Neuromag Software only appeared in the lateral temporal lobe. Thus, the proposed algorithm maybe become an effective method in detecting deeper epileptogenic zone.

Original languageEnglish
Title of host publicationAdvanced Computational Methods in Life System Modeling and Simulation - International Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017, Proceedings
EditorsMinrui Fei, Shiwei Ma, Xin Li, Xin Sun, Li Jia, Zhou Su
PublisherSpringer Verlag
Pages536-544
Number of pages9
ISBN (Print)9789811063695
DOIs
StatePublished - 2017
EventInternational Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017 - Nanjing, China
Duration: 22 Sep 201724 Sep 2017

Publication series

NameCommunications in Computer and Information Science
Volume761
ISSN (Print)1865-0929

Conference

ConferenceInternational Conference on Life System Modeling and Simulation, LSMS 2017 and International Conference on Intelligent Computing for Sustainable Energy and Environment, ICSEE 2017
Country/TerritoryChina
CityNanjing
Period22/09/1724/09/17

Keywords

  • Epileptogenic zone
  • Magnetic source imaging
  • Magnetoencephalography
  • Mesial temporal lobe epilepsy

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