Mechanical properties, degradation behaviors and biocompatibility of micro-alloyed Mg-Sr-RE alloys for stent applications

Hongyan Tang; Fan Wang; Dan Li; Xuenan Gu; Yubo Fan

doi:10.1016/j.matlet.2019.127285

Mechanical properties, degradation behaviors and biocompatibility of micro-alloyed Mg-Sr-RE alloys for stent applications

Hongyan Tang
, Fan Wang
, Dan Li
, Xuenan Gu^*
, Yubo Fan

^*Corresponding author for this work

Beihang University
National Research Center for Rehabilitation Technical Aids

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

This article describes the development of Mg-Sr-RE (RE = La, Nd, Gd) alloys based on a microalloying strategy for stent applications, which aims to control the biosafety and improve the degradation simultaneously. The results reveal that the designed Mg-Sr-RE alloys are close to a single-phase solid solution with the total alloying addition restricted to 0.5 wt%. Mg-Sr-RE alloy exhibits 0.5–2 times increment of ductility while 45–66% slower corrosion rates than binary Mg-Sr. Both the indirect and direct cell assays indicate that Mg-Sr-RE alloys reduce HAVSMCs proliferation, stimulate the HUVECs growth and endothelialization related gene expression, which may benefit in the healing of stent-assisted vascular injuries.

Original language	English
Article number	127285
Journal	Materials Letters
Volume	264
DOIs	https://doi.org/10.1016/j.matlet.2019.127285
State	Published - 1 Apr 2020

Keywords

Biomaterials
Corrosion
Endothelial cell
Magnesium alloy
Micro-alloyed

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10.1016/j.matlet.2019.127285

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title = "Mechanical properties, degradation behaviors and biocompatibility of micro-alloyed Mg-Sr-RE alloys for stent applications",

abstract = "This article describes the development of Mg-Sr-RE (RE = La, Nd, Gd) alloys based on a microalloying strategy for stent applications, which aims to control the biosafety and improve the degradation simultaneously. The results reveal that the designed Mg-Sr-RE alloys are close to a single-phase solid solution with the total alloying addition restricted to 0.5 wt\%. Mg-Sr-RE alloy exhibits 0.5–2 times increment of ductility while 45–66\% slower corrosion rates than binary Mg-Sr. Both the indirect and direct cell assays indicate that Mg-Sr-RE alloys reduce HAVSMCs proliferation, stimulate the HUVECs growth and endothelialization related gene expression, which may benefit in the healing of stent-assisted vascular injuries.",

keywords = "Biomaterials, Corrosion, Endothelial cell, Magnesium alloy, Micro-alloyed",

author = "Hongyan Tang and Fan Wang and Dan Li and Xuenan Gu and Yubo Fan",

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doi = "10.1016/j.matlet.2019.127285",

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journal = "Materials Letters",

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TY - JOUR

T1 - Mechanical properties, degradation behaviors and biocompatibility of micro-alloyed Mg-Sr-RE alloys for stent applications

AU - Tang, Hongyan

AU - Wang, Fan

AU - Li, Dan

AU - Gu, Xuenan

AU - Fan, Yubo

PY - 2020/4/1

Y1 - 2020/4/1

N2 - This article describes the development of Mg-Sr-RE (RE = La, Nd, Gd) alloys based on a microalloying strategy for stent applications, which aims to control the biosafety and improve the degradation simultaneously. The results reveal that the designed Mg-Sr-RE alloys are close to a single-phase solid solution with the total alloying addition restricted to 0.5 wt%. Mg-Sr-RE alloy exhibits 0.5–2 times increment of ductility while 45–66% slower corrosion rates than binary Mg-Sr. Both the indirect and direct cell assays indicate that Mg-Sr-RE alloys reduce HAVSMCs proliferation, stimulate the HUVECs growth and endothelialization related gene expression, which may benefit in the healing of stent-assisted vascular injuries.

AB - This article describes the development of Mg-Sr-RE (RE = La, Nd, Gd) alloys based on a microalloying strategy for stent applications, which aims to control the biosafety and improve the degradation simultaneously. The results reveal that the designed Mg-Sr-RE alloys are close to a single-phase solid solution with the total alloying addition restricted to 0.5 wt%. Mg-Sr-RE alloy exhibits 0.5–2 times increment of ductility while 45–66% slower corrosion rates than binary Mg-Sr. Both the indirect and direct cell assays indicate that Mg-Sr-RE alloys reduce HAVSMCs proliferation, stimulate the HUVECs growth and endothelialization related gene expression, which may benefit in the healing of stent-assisted vascular injuries.

KW - Biomaterials

KW - Corrosion

KW - Endothelial cell

KW - Magnesium alloy

KW - Micro-alloyed

UR - https://www.scopus.com/pages/publications/85077680274

U2 - 10.1016/j.matlet.2019.127285

DO - 10.1016/j.matlet.2019.127285

M3 - 文章

AN - SCOPUS:85077680274

SN - 0167-577X

VL - 264

JO - Materials Letters

JF - Materials Letters

M1 - 127285

ER -

Mechanical properties, degradation behaviors and biocompatibility of micro-alloyed Mg-Sr-RE alloys for stent applications

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Keywords

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