Mapping the calcification of bovine pericardium in rat model by enhanced micro-computed tomography

Jing Liu; Shengping Zhong; Hualin Lan; Xu Meng; Haibo Zhang; Yubo Fan; Yuxing Wang; Chunren Wang; Zhaoxu Wang

doi:10.1016/j.biomaterials.2014.06.026

Mapping the calcification of bovine pericardium in rat model by enhanced micro-computed tomography

Jing Liu
, Shengping Zhong
, Hualin Lan
, Xu Meng
, Haibo Zhang
, Yubo Fan
, Yuxing Wang
, Chunren Wang
, Zhaoxu Wang^*

^*Corresponding author for this work

School of Engineering Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The calcification initiation and progression of bioprosthetic heart valve were investigated in a rat model by enhanced micro-computed tomography, together with histologic study and scanning electron microscope analysis. The implantation data at early stage showed apparent dendritic patterns in the radiographic images for the glutaraldehyde-treated bovine pericardium and this dendritic pattern was verified to be associated with the vessel distribution in the tissue. Histologic study and scanning electron microscope analysis both indicated that the calcium deposits in the pericardium vessels regions were more grievous than those scattered in the collagen fibers in the first two weeks after implantation. Subsequently, calcification spreaded and the entire sample was severely calcified in 60 days.

Original language	English
Pages (from-to)	8305-8311
Number of pages	7
Journal	Biomaterials
Volume	35
Issue number	29
DOIs	https://doi.org/10.1016/j.biomaterials.2014.06.026
State	Published - Sep 2014

Keywords

Bioprosthetic heart valve
Bovine pericardium
Calcification
Micro-computed tomography (micro-CT)

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10.1016/j.biomaterials.2014.06.026

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title = "Mapping the calcification of bovine pericardium in rat model by enhanced micro-computed tomography",

abstract = "The calcification initiation and progression of bioprosthetic heart valve were investigated in a rat model by enhanced micro-computed tomography, together with histologic study and scanning electron microscope analysis. The implantation data at early stage showed apparent dendritic patterns in the radiographic images for the glutaraldehyde-treated bovine pericardium and this dendritic pattern was verified to be associated with the vessel distribution in the tissue. Histologic study and scanning electron microscope analysis both indicated that the calcium deposits in the pericardium vessels regions were more grievous than those scattered in the collagen fibers in the first two weeks after implantation. Subsequently, calcification spreaded and the entire sample was severely calcified in 60 days.",

keywords = "Bioprosthetic heart valve, Bovine pericardium, Calcification, Micro-computed tomography (micro-CT)",

author = "Jing Liu and Shengping Zhong and Hualin Lan and Xu Meng and Haibo Zhang and Yubo Fan and Yuxing Wang and Chunren Wang and Zhaoxu Wang",

year = "2014",

month = sep,

doi = "10.1016/j.biomaterials.2014.06.026",

language = "英语",

volume = "35",

pages = "8305--8311",

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TY - JOUR

T1 - Mapping the calcification of bovine pericardium in rat model by enhanced micro-computed tomography

AU - Liu, Jing

AU - Zhong, Shengping

AU - Lan, Hualin

AU - Meng, Xu

AU - Zhang, Haibo

AU - Fan, Yubo

AU - Wang, Yuxing

AU - Wang, Chunren

AU - Wang, Zhaoxu

PY - 2014/9

Y1 - 2014/9

N2 - The calcification initiation and progression of bioprosthetic heart valve were investigated in a rat model by enhanced micro-computed tomography, together with histologic study and scanning electron microscope analysis. The implantation data at early stage showed apparent dendritic patterns in the radiographic images for the glutaraldehyde-treated bovine pericardium and this dendritic pattern was verified to be associated with the vessel distribution in the tissue. Histologic study and scanning electron microscope analysis both indicated that the calcium deposits in the pericardium vessels regions were more grievous than those scattered in the collagen fibers in the first two weeks after implantation. Subsequently, calcification spreaded and the entire sample was severely calcified in 60 days.

AB - The calcification initiation and progression of bioprosthetic heart valve were investigated in a rat model by enhanced micro-computed tomography, together with histologic study and scanning electron microscope analysis. The implantation data at early stage showed apparent dendritic patterns in the radiographic images for the glutaraldehyde-treated bovine pericardium and this dendritic pattern was verified to be associated with the vessel distribution in the tissue. Histologic study and scanning electron microscope analysis both indicated that the calcium deposits in the pericardium vessels regions were more grievous than those scattered in the collagen fibers in the first two weeks after implantation. Subsequently, calcification spreaded and the entire sample was severely calcified in 60 days.

KW - Bioprosthetic heart valve

KW - Bovine pericardium

KW - Calcification

KW - Micro-computed tomography (micro-CT)

UR - https://www.scopus.com/pages/publications/84904097180

U2 - 10.1016/j.biomaterials.2014.06.026

DO - 10.1016/j.biomaterials.2014.06.026

M3 - 文章

C2 - 24973299

AN - SCOPUS:84904097180

SN - 0142-9612

VL - 35

SP - 8305

EP - 8311

JO - Biomaterials

JF - Biomaterials

IS - 29

ER -

Mapping the calcification of bovine pericardium in rat model by enhanced micro-computed tomography

Abstract

Keywords

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