Localized motion imaging for monitoring HIFU therapy: Comparison of modulating frequencies and utilization of square modulating wave

High-intensity focused ultrasound (HIFU) has been successfully used as a minimally invasive cancer therapy method. For monitoring the therapy, the amplitude-modulated (AM) localized motion imaging (LMI) method had been proposed. This paper compares the performance of AM-LMI while using different sine modulating wave frequencies and proposes the utilization of square modulating waves to gain the advantages of both high and low modulating frequencies. A single element therapy transducer with a 2 MHz central frequency was driven by sine modulating waves with different frequencies (approximate 34, 67, 102, 168, and 201 Hz) and by square modulating waves with two frequencies (34 and 67 Hz). An imaging probe with a 5 MHz central frequency and a 20 MHz sampling frequency was mounted in the center hole of the therapy transducer to acquire pulse-echo data, which were used to estimate the tissue oscillation amplitude induced by the acoustic radiation force of the HIFU beam. The decrease ratio of the oscillation amount was then utilized to estimate the coagulated lesion length during the therapy. The comparison of modulating frequencies demonstrated that a higher frequency could bring higher sensitivity to small lesions, while a lower frequency not only gives greater noise robustness but also promotes the ability to estimate lengths of larger lesions. The utilization of a square modulating wave demonstrated its utility to produce tissue oscillation with multiple frequencies and gain the advantages of both high and low modulating frequencies.