TY - JOUR
T1 - Linking changes in sulcal morphometry to cognitive development from childhood to adolescence
AU - Shan, Yijin
AU - Qiao, Huiting
AU - He, Yirong
AU - Chu, Lei
AU - Zeng, Debin
AU - Dong, Xiaoxi
AU - Zhao, Tengda
AU - Liao, Xuhong
AU - Chen, Xiaodan
AU - Xia, Yunman
AU - Lei, Tianyuan
AU - Sun, Lianglong
AU - Men, Weiwei
AU - Chen, Rui
AU - Ma, Leilei
AU - Ren, Xiaoyu
AU - Wang, Yanpei
AU - Wang, Daoyang
AU - Hu, Mingming
AU - Pan, Zhiying
AU - Tan, Shuping
AU - Gao, Jia Hong
AU - Qin, Shaozheng
AU - Tao, Sha
AU - Dong, Qi
AU - He, Yong
AU - Li, Shuyu
N1 - Publisher Copyright:
© The Author(s) 2026.
PY - 2026/12
Y1 - 2026/12
N2 - Despite dynamic sulcal changes during youth paralleling skill development, the link between extended postnatal development and cognition remains underexplored. This study analyzes structural MRI data from 307 children (6-14 years), with longitudinal data (inter-scan interval ~1 year) available for a subset. Results reveal widespread cortical thinning, sulcal widening, and reductions in adjusted area and depth, following a chronological gradient where earliest-forming sulci undergo the most profound change. Longitudinal remodeling, rather than baseline morphometry, predicts cognitive gains. Specifically, working memory improvements are predicted by widening of the left calcarine and posterior intralingual sulci. In contrast, attention network maturation involves global changes, though executive control is specifically linked to left intraparietal sulcus widening. Gene enrichment analysis links these changes to synaptic processes. This study advances our understanding of the association between sulcal morphometry and cognitive function, elucidating potential mechanisms underlying brain development from childhood to adolescence.
AB - Despite dynamic sulcal changes during youth paralleling skill development, the link between extended postnatal development and cognition remains underexplored. This study analyzes structural MRI data from 307 children (6-14 years), with longitudinal data (inter-scan interval ~1 year) available for a subset. Results reveal widespread cortical thinning, sulcal widening, and reductions in adjusted area and depth, following a chronological gradient where earliest-forming sulci undergo the most profound change. Longitudinal remodeling, rather than baseline morphometry, predicts cognitive gains. Specifically, working memory improvements are predicted by widening of the left calcarine and posterior intralingual sulci. In contrast, attention network maturation involves global changes, though executive control is specifically linked to left intraparietal sulcus widening. Gene enrichment analysis links these changes to synaptic processes. This study advances our understanding of the association between sulcal morphometry and cognitive function, elucidating potential mechanisms underlying brain development from childhood to adolescence.
UR - https://www.scopus.com/pages/publications/105040829859
U2 - 10.1038/s42003-026-09956-6
DO - 10.1038/s42003-026-09956-6
M3 - 文章
AN - SCOPUS:105040829859
SN - 2399-3642
VL - 9
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 767
ER -