Input function for [¹⁸F]2-fluoro-2-deoxy-Z)-glucose (FDG) dynamic study

Accurate noninvasive determination of input curves is important in metabolic research of [¹⁸F]2-fluoro-2-deoxy-D-glucose (FDG) metabolism in vivo using positron emission tomography (PET). The method combines the region of interest method for dynamic imaging with a standard input function to confirm the input curve. First, a 3-D volume of interest (VOI) is selected in one part of the aorta far from the main metabolic organ. Then the temporal blood activity curve obtained from the VOI is fit to the population-based standard input function to confirm the input curve. Simulation studies used 200 sets of data with various noise and spillover effects to validate the method's validity. The method has been used with 6 sets of data with reasonable results.