Influence of mechanical fixation on angiogenesis during bone healing process

Zhi Lun Zhou; Feng Zhao; Yang Yan; Zhen Yuan; Guan Zhong Yang; Hao Yu; Hao Su; Tao Zhang; Yubo Fan

doi:10.1007/978-3-319-12262-5_31

Influence of mechanical fixation on angiogenesis during bone healing process

Zhi Lun Zhou
, Feng Zhao
, Yang Yan
, Zhen Yuan
, Guan Zhong Yang
, Hao Yu
, Hao Su
, Tao Zhang
, Yubo Fan^*

^*Corresponding author for this work

Beihang University
Tianjin Medical University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

During bone fracture healing, both angiogenesis and mechanical fixation are of great significance. This study aims to obtain 3D structure of vascular network surrounding the fracture site at different healing times using vascular perfusion and micro-CT imaging technology, and to explore the influence of mechanical fixation on 3D structure of vascular network at the fracture site. To achieve the goal, transverse fracture surgery were performed on thirty six SD rats’ right tibias. Half of them (SF) received stable fixation with a newly custom-designed circular external fixator and the rest (NF) didn’t received any fixation devices. The imaging results indicated that compared with NF samples, SF samples contained more vascular distribution along the tibia, inferring a much more similar 3D structure to the CON samples (all of the thirty six rats’ left posterior limbs were taken as control group), which tends to be beneficial to the vascular reconstruction at the fracture site.

Original language	English
Title of host publication	1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
Editors	Fong-Chin Su, Ming-Long Yeh, Shyh-Hau Wang
Publisher	Springer Verlag
Pages	111-113
Number of pages	3
ISBN (Electronic)	9783319122618
DOIs	https://doi.org/10.1007/978-3-319-12262-5_31
State	Published - 2015
Event	1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan, Province of China Duration: 9 Oct 2014 → 12 Oct 2014

Publication series

Name	IFMBE Proceedings
Volume	47
ISSN (Print)	1680-0737
ISSN (Electronic)	1433-9277

Conference

Conference	1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
Country/Territory	Taiwan, Province of China
City	Tainan
Period	9/10/14 → 12/10/14

Keywords

3D structure
Angiogenesis
Mechanical fixation
Micro-CT imaging
Vascular perfusion

Access to Document

10.1007/978-3-319-12262-5_31

Cite this

Zhou, Z. L., Zhao, F., Yan, Y., Yuan, Z., Yang, G. Z., Yu, H., Su, H., Zhang, T., & Fan, Y. (2015). Influence of mechanical fixation on angiogenesis during bone healing process. In F.-C. Su, M.-L. Yeh, & S.-H. Wang (Eds.), 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering (pp. 111-113). (IFMBE Proceedings; Vol. 47). Springer Verlag. https://doi.org/10.1007/978-3-319-12262-5_31

@inproceedings{92326964446847bc92a362bf0ec4c0cf,

title = "Influence of mechanical fixation on angiogenesis during bone healing process",

abstract = "During bone fracture healing, both angiogenesis and mechanical fixation are of great significance. This study aims to obtain 3D structure of vascular network surrounding the fracture site at different healing times using vascular perfusion and micro-CT imaging technology, and to explore the influence of mechanical fixation on 3D structure of vascular network at the fracture site. To achieve the goal, transverse fracture surgery were performed on thirty six SD rats{\textquoteright} right tibias. Half of them (SF) received stable fixation with a newly custom-designed circular external fixator and the rest (NF) didn{\textquoteright}t received any fixation devices. The imaging results indicated that compared with NF samples, SF samples contained more vascular distribution along the tibia, inferring a much more similar 3D structure to the CON samples (all of the thirty six rats{\textquoteright} left posterior limbs were taken as control group), which tends to be beneficial to the vascular reconstruction at the fracture site.",

keywords = "3D structure, Angiogenesis, Mechanical fixation, Micro-CT imaging, Vascular perfusion",

author = "Zhou, \{Zhi Lun\} and Feng Zhao and Yang Yan and Zhen Yuan and Yang, \{Guan Zhong\} and Hao Yu and Hao Su and Tao Zhang and Yubo Fan",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2015.; 1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 ; Conference date: 09-10-2014 Through 12-10-2014",

year = "2015",

doi = "10.1007/978-3-319-12262-5\_31",

language = "英语",

series = "IFMBE Proceedings",

publisher = "Springer Verlag",

pages = "111--113",

editor = "Fong-Chin Su and Ming-Long Yeh and Shyh-Hau Wang",

booktitle = "1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering",

address = "德国",

}

Zhou, ZL, Zhao, F, Yan, Y, Yuan, Z, Yang, GZ, Yu, H, Su, H, Zhang, T & Fan, Y 2015, Influence of mechanical fixation on angiogenesis during bone healing process. in F-C Su, M-L Yeh & S-H Wang (eds), 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings, vol. 47, Springer Verlag, pp. 111-113, 1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014, Tainan, Taiwan, Province of China, 9/10/14. https://doi.org/10.1007/978-3-319-12262-5_31

Influence of mechanical fixation on angiogenesis during bone healing process. / Zhou, Zhi Lun; Zhao, Feng; Yan, Yang et al.
1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. ed. / Fong-Chin Su; Ming-Long Yeh; Shyh-Hau Wang. Springer Verlag, 2015. p. 111-113 (IFMBE Proceedings; Vol. 47).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Influence of mechanical fixation on angiogenesis during bone healing process

AU - Zhou, Zhi Lun

AU - Zhao, Feng

AU - Yan, Yang

AU - Yuan, Zhen

AU - Yang, Guan Zhong

AU - Yu, Hao

AU - Su, Hao

AU - Zhang, Tao

AU - Fan, Yubo

N1 - Publisher Copyright: © Springer International Publishing Switzerland 2015.

PY - 2015

Y1 - 2015

N2 - During bone fracture healing, both angiogenesis and mechanical fixation are of great significance. This study aims to obtain 3D structure of vascular network surrounding the fracture site at different healing times using vascular perfusion and micro-CT imaging technology, and to explore the influence of mechanical fixation on 3D structure of vascular network at the fracture site. To achieve the goal, transverse fracture surgery were performed on thirty six SD rats’ right tibias. Half of them (SF) received stable fixation with a newly custom-designed circular external fixator and the rest (NF) didn’t received any fixation devices. The imaging results indicated that compared with NF samples, SF samples contained more vascular distribution along the tibia, inferring a much more similar 3D structure to the CON samples (all of the thirty six rats’ left posterior limbs were taken as control group), which tends to be beneficial to the vascular reconstruction at the fracture site.

AB - During bone fracture healing, both angiogenesis and mechanical fixation are of great significance. This study aims to obtain 3D structure of vascular network surrounding the fracture site at different healing times using vascular perfusion and micro-CT imaging technology, and to explore the influence of mechanical fixation on 3D structure of vascular network at the fracture site. To achieve the goal, transverse fracture surgery were performed on thirty six SD rats’ right tibias. Half of them (SF) received stable fixation with a newly custom-designed circular external fixator and the rest (NF) didn’t received any fixation devices. The imaging results indicated that compared with NF samples, SF samples contained more vascular distribution along the tibia, inferring a much more similar 3D structure to the CON samples (all of the thirty six rats’ left posterior limbs were taken as control group), which tends to be beneficial to the vascular reconstruction at the fracture site.

KW - 3D structure

KW - Angiogenesis

KW - Mechanical fixation

KW - Micro-CT imaging

KW - Vascular perfusion

UR - https://www.scopus.com/pages/publications/84914815530

U2 - 10.1007/978-3-319-12262-5_31

DO - 10.1007/978-3-319-12262-5_31

M3 - 会议稿件

AN - SCOPUS:84914815530

T3 - IFMBE Proceedings

SP - 111

EP - 113

BT - 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering

A2 - Su, Fong-Chin

A2 - Yeh, Ming-Long

A2 - Wang, Shyh-Hau

PB - Springer Verlag

T2 - 1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014

Y2 - 9 October 2014 through 12 October 2014

ER -

Zhou ZL, Zhao F, Yan Y, Yuan Z, Yang GZ, Yu H et al. Influence of mechanical fixation on angiogenesis during bone healing process. In Su FC, Yeh ML, Wang SH, editors, 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. Springer Verlag. 2015. p. 111-113. (IFMBE Proceedings). doi: 10.1007/978-3-319-12262-5_31

Influence of mechanical fixation on angiogenesis during bone healing process

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Keywords

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