Influence of Heart Rate on Dynamic Characteristics and Hemolytic Potential: A Study Using In-Vitro and Numerical Methods

Shulei Li; Donghai Jin; Xingmin Gui; Guangmao Liu; Jianqiang Hao; Xihang Jiang

doi:10.1109/TBME.2024.3467924

Influence of Heart Rate on Dynamic Characteristics and Hemolytic Potential: A Study Using In-Vitro and Numerical Methods

Shulei Li
, Donghai Jin^*
, Xingmin Gui
, Guangmao Liu^*
, Jianqiang Hao
, Xihang Jiang

^*Corresponding author for this work

School of Energy and Power Engineering

Beihang University
Joint Research Center for Cardiovascular Fluid Dynamics
Chinese Academy of Medical Sciences
Beijing Power Machinery Research Institute

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objective: This study investigates the influence of heart rate (HR) on the pump at the coupled working state with the cardiovascular system. Methods: A combined approach integrating in-vitro and numerical methods is employed to predict cycle-average hemolytic potential (denoted as HI_ave). The pump dynamic characteristics under varying HR conditions are investigated in the in-vitro experiments. The hemolytic potential at different operation points (represented by HI) are predicted numerically. Results: HR variations affect the shape of the pump dynamic characteristic loop and the cycle-average hemolytic potential. Specifically, in all three series studied, HI_ave demonstrated an increase from 60 to 80 bpm and a decrease from 100 to 120 bpm. Conclusion: Higher HR correlates with heightened hysteresis effects within turbomachinery, thereby impacting the dynamic characteristics' profile. Significance: This study unveils the physical mechanisms underlying the influence of HR on pump dynamic characteristics and provides crucial insights for estimating potential adverse effects associated with left ventricular assist device (LVAD) implantation under diverse HR conditions, which helps prompt pump adjustments in clinical applications and the development of coupled working models.

Original language	English
Pages (from-to)	689-704
Number of pages	16
Journal	IEEE Transactions on Biomedical Engineering
Volume	72
Issue number	2
DOIs	https://doi.org/10.1109/TBME.2024.3467924
State	Published - 2025

Keywords

Heart rate
hemolytic potential
in-vitro experiments
numerical simulations
pump dynamic characteristics

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title = "Influence of Heart Rate on Dynamic Characteristics and Hemolytic Potential: A Study Using In-Vitro and Numerical Methods",

abstract = "Objective: This study investigates the influence of heart rate (HR) on the pump at the coupled working state with the cardiovascular system. Methods: A combined approach integrating in-vitro and numerical methods is employed to predict cycle-average hemolytic potential (denoted as HIave). The pump dynamic characteristics under varying HR conditions are investigated in the in-vitro experiments. The hemolytic potential at different operation points (represented by HI) are predicted numerically. Results: HR variations affect the shape of the pump dynamic characteristic loop and the cycle-average hemolytic potential. Specifically, in all three series studied, HIave demonstrated an increase from 60 to 80 bpm and a decrease from 100 to 120 bpm. Conclusion: Higher HR correlates with heightened hysteresis effects within turbomachinery, thereby impacting the dynamic characteristics' profile. Significance: This study unveils the physical mechanisms underlying the influence of HR on pump dynamic characteristics and provides crucial insights for estimating potential adverse effects associated with left ventricular assist device (LVAD) implantation under diverse HR conditions, which helps prompt pump adjustments in clinical applications and the development of coupled working models.",

keywords = "Heart rate, hemolytic potential, in-vitro experiments, numerical simulations, pump dynamic characteristics",

author = "Shulei Li and Donghai Jin and Xingmin Gui and Guangmao Liu and Jianqiang Hao and Xihang Jiang",

note = "Publisher Copyright: {\textcopyright} 1964-2012 IEEE.",

year = "2025",

doi = "10.1109/TBME.2024.3467924",

language = "英语",

volume = "72",

pages = "689--704",

journal = "IEEE Transactions on Biomedical Engineering",

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T2 - A Study Using In-Vitro and Numerical Methods

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AU - Jin, Donghai

AU - Gui, Xingmin

AU - Liu, Guangmao

AU - Hao, Jianqiang

AU - Jiang, Xihang

PY - 2025

Y1 - 2025

N2 - Objective: This study investigates the influence of heart rate (HR) on the pump at the coupled working state with the cardiovascular system. Methods: A combined approach integrating in-vitro and numerical methods is employed to predict cycle-average hemolytic potential (denoted as HIave). The pump dynamic characteristics under varying HR conditions are investigated in the in-vitro experiments. The hemolytic potential at different operation points (represented by HI) are predicted numerically. Results: HR variations affect the shape of the pump dynamic characteristic loop and the cycle-average hemolytic potential. Specifically, in all three series studied, HIave demonstrated an increase from 60 to 80 bpm and a decrease from 100 to 120 bpm. Conclusion: Higher HR correlates with heightened hysteresis effects within turbomachinery, thereby impacting the dynamic characteristics' profile. Significance: This study unveils the physical mechanisms underlying the influence of HR on pump dynamic characteristics and provides crucial insights for estimating potential adverse effects associated with left ventricular assist device (LVAD) implantation under diverse HR conditions, which helps prompt pump adjustments in clinical applications and the development of coupled working models.

AB - Objective: This study investigates the influence of heart rate (HR) on the pump at the coupled working state with the cardiovascular system. Methods: A combined approach integrating in-vitro and numerical methods is employed to predict cycle-average hemolytic potential (denoted as HIave). The pump dynamic characteristics under varying HR conditions are investigated in the in-vitro experiments. The hemolytic potential at different operation points (represented by HI) are predicted numerically. Results: HR variations affect the shape of the pump dynamic characteristic loop and the cycle-average hemolytic potential. Specifically, in all three series studied, HIave demonstrated an increase from 60 to 80 bpm and a decrease from 100 to 120 bpm. Conclusion: Higher HR correlates with heightened hysteresis effects within turbomachinery, thereby impacting the dynamic characteristics' profile. Significance: This study unveils the physical mechanisms underlying the influence of HR on pump dynamic characteristics and provides crucial insights for estimating potential adverse effects associated with left ventricular assist device (LVAD) implantation under diverse HR conditions, which helps prompt pump adjustments in clinical applications and the development of coupled working models.

KW - Heart rate

KW - hemolytic potential

KW - in-vitro experiments

KW - numerical simulations

KW - pump dynamic characteristics

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DO - 10.1109/TBME.2024.3467924

M3 - 文章

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JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

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ER -

Influence of Heart Rate on Dynamic Characteristics and Hemolytic Potential: A Study Using In-Vitro and Numerical Methods

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