Abstract
BACKGROUND: Induced pluripotent stem cells have great prospects in tissue repair, due to the characteristic of self-renewal, multi-directional differentiation, no immunological rejection and ethics controversy. OBJECTIVE: To summarize the differentiation of induced pluripotent stem cells towards cardiomyocytes and endothelial cells, and their applications in the cardiovascular diseases. METHODS: The first author performed a data retrieval of PubMed and CNKI databases from 2000 to 2015 to search articles addressing the differentiation of induced pluripotent stem cells towards cardiomyocytes and endothelial cells, and reviewed the literatures systematically. Finally, 78 articles were chosen for further analysis. RESULTS AND CONCLUSION: Induced pluripotent stem cells can differentiate into cardiovascular cells through a variety of methods. Factors such as cyclosporin A and ascorbic acid C may improve myocardial differentiation of induced pluripotent stem cells, while vascular endothelial growth factor and basic fibroblast growth factor may improve the endothelial differentiation of induced pluripotent stem cells. Cardiovascular cells derived from induced pluripotent stem cells can be applied to build disease models in vitro, transplantation in vivo and drug screening.
| Original language | English |
|---|---|
| Pages (from-to) | 5440-5449 |
| Number of pages | 10 |
| Journal | Chinese Journal of Tissue Engineering Research |
| Volume | 20 |
| Issue number | 36 |
| DOIs | |
| State | Published - 2016 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cardiac
- Cell Differentiation
- Endothelial Cells
- Induced Pluripotent Stem Cells
- Myocytes
- Tissue Engineering
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