In vitro degradation of butanediamine-grafted poly(DL-Lactic acids)

Yanfeng Luo; Chunhua Fu; Xufeng Niu; Yuanliang Wang

doi:10.1007/s11595-006-3426-2

In vitro degradation of butanediamine-grafted poly(DL-Lactic acids)

Yanfeng Luo^*
, Chunhua Fu
, Xufeng Niu
, Yuanliang Wang

^*Corresponding author for this work

Chongqing University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The degradation of butanediamine-grafted poly(DL-lactic acid) polymers (BDPLAs) in vitro together with PDLLA and maleic anhydride-grafted poly(DL-lactic acid) polymers (MPLAs) was investigated by observation of the changes of the pH value of incubation media, and weight loss ratio during degradation duration of 12 weeks. The results reveal that the acidity of PDLLA degradation products was weakened or neutralized by grafting butanediamine onto PDLLA. A uniform degradation of BDPLAs was observed in comparison with an acidity-induced auto-accelerating degradation featured by PDLLA and MPLAs. The biodegradation behaviors of BDPLAs can be adjusted by controlling the content of BDA. BDPLAs might be a new derivative of PDLLA-based biodegradable materials for medical applications without acidity-caused irritations and acidity-induced auto-accelerating degradation behavior as that of PDLLA.

Original language	English
Pages (from-to)	426-430
Number of pages	5
Journal	Journal Wuhan University of Technology, Materials Science Edition
Volume	22
Issue number	3
DOIs	https://doi.org/10.1007/s11595-006-3426-2
State	Published - Sep 2007
Externally published	Yes

Keywords

Butanediamine
In vitro biodegradation
Maleic anhydride
Poly(DL-lactic acid)

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10.1007/s11595-006-3426-2

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title = "In vitro degradation of butanediamine-grafted poly(DL-Lactic acids)",

abstract = "The degradation of butanediamine-grafted poly(DL-lactic acid) polymers (BDPLAs) in vitro together with PDLLA and maleic anhydride-grafted poly(DL-lactic acid) polymers (MPLAs) was investigated by observation of the changes of the pH value of incubation media, and weight loss ratio during degradation duration of 12 weeks. The results reveal that the acidity of PDLLA degradation products was weakened or neutralized by grafting butanediamine onto PDLLA. A uniform degradation of BDPLAs was observed in comparison with an acidity-induced auto-accelerating degradation featured by PDLLA and MPLAs. The biodegradation behaviors of BDPLAs can be adjusted by controlling the content of BDA. BDPLAs might be a new derivative of PDLLA-based biodegradable materials for medical applications without acidity-caused irritations and acidity-induced auto-accelerating degradation behavior as that of PDLLA.",

keywords = "Butanediamine, In vitro biodegradation, Maleic anhydride, Poly(DL-lactic acid)",

author = "Yanfeng Luo and Chunhua Fu and Xufeng Niu and Yuanliang Wang",

year = "2007",

month = sep,

doi = "10.1007/s11595-006-3426-2",

language = "英语",

volume = "22",

pages = "426--430",

journal = "Journal Wuhan University of Technology, Materials Science Edition",

issn = "1000-2413",

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}

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T1 - In vitro degradation of butanediamine-grafted poly(DL-Lactic acids)

AU - Luo, Yanfeng

AU - Fu, Chunhua

AU - Niu, Xufeng

AU - Wang, Yuanliang

PY - 2007/9

Y1 - 2007/9

N2 - The degradation of butanediamine-grafted poly(DL-lactic acid) polymers (BDPLAs) in vitro together with PDLLA and maleic anhydride-grafted poly(DL-lactic acid) polymers (MPLAs) was investigated by observation of the changes of the pH value of incubation media, and weight loss ratio during degradation duration of 12 weeks. The results reveal that the acidity of PDLLA degradation products was weakened or neutralized by grafting butanediamine onto PDLLA. A uniform degradation of BDPLAs was observed in comparison with an acidity-induced auto-accelerating degradation featured by PDLLA and MPLAs. The biodegradation behaviors of BDPLAs can be adjusted by controlling the content of BDA. BDPLAs might be a new derivative of PDLLA-based biodegradable materials for medical applications without acidity-caused irritations and acidity-induced auto-accelerating degradation behavior as that of PDLLA.

AB - The degradation of butanediamine-grafted poly(DL-lactic acid) polymers (BDPLAs) in vitro together with PDLLA and maleic anhydride-grafted poly(DL-lactic acid) polymers (MPLAs) was investigated by observation of the changes of the pH value of incubation media, and weight loss ratio during degradation duration of 12 weeks. The results reveal that the acidity of PDLLA degradation products was weakened or neutralized by grafting butanediamine onto PDLLA. A uniform degradation of BDPLAs was observed in comparison with an acidity-induced auto-accelerating degradation featured by PDLLA and MPLAs. The biodegradation behaviors of BDPLAs can be adjusted by controlling the content of BDA. BDPLAs might be a new derivative of PDLLA-based biodegradable materials for medical applications without acidity-caused irritations and acidity-induced auto-accelerating degradation behavior as that of PDLLA.

KW - Butanediamine

KW - In vitro biodegradation

KW - Maleic anhydride

KW - Poly(DL-lactic acid)

UR - https://www.scopus.com/pages/publications/34948888621

U2 - 10.1007/s11595-006-3426-2

DO - 10.1007/s11595-006-3426-2

M3 - 文章

AN - SCOPUS:34948888621

SN - 1000-2413

VL - 22

SP - 426

EP - 430

JO - Journal Wuhan University of Technology, Materials Science Edition

JF - Journal Wuhan University of Technology, Materials Science Edition

IS - 3

ER -

In vitro degradation of butanediamine-grafted poly(DL-Lactic acids)

Abstract

Keywords

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