Genomewide expression profile analysis in different TNM stages of lung adenocarcinoma

Xiaoli Zhang; Hong Pan; Feng Zhang; Yongbiao Zhang; Yang Zhang; Han Xia; Jing Zhu; Weiling Fu; Ming Liu

doi:10.2495/HHME130361

Genomewide expression profile analysis in different TNM stages of lung adenocarcinoma

Xiaoli Zhang
, Hong Pan
, Feng Zhang
, Yongbiao Zhang
, Yang Zhang
, Han Xia
, Jing Zhu
, Weiling Fu
, Ming Liu

Army Medical University
CAS - Beijing Institute of Genomics
General Hospital of People's Liberation Army
Daping Hospital, the Third Military Medical University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Most of the gene array-based expression studies of lung cancer have ignored the differences in clinical features, for example the Tumor-Node-Metastasis (TNM) stages of the cancer. In this study, we used a 35K Oligo gene array to identify the differentially expressed genes associated with different TNM stages in lung adenocarcinomas, a subtype with increasing incidence in recent years in China. We identified 10 differentially expressed genes among 90 tumor samples of lung adenocarcinoma at various TNM stages (Stage I, II, and IIIA), of which Zimp7, GINS2, and NAG-1 genes were first reported to be present at a high level in lung adenocarcinoma, and these three genes were confirmed by real-time RT-PCR in a different set of samples. These 10 candidate genes associated with different TNM stages in lung adenocarcinoma in the Chinese population may offer new targets for the diagnosis, therapy, and prognosis prediction of lung adenocarcinoma.

Original language	English
Title of host publication	Human Health and Medical Engineering
Editors	Zhenyu Du, Maozhu Jin
Publisher	WITPress
Pages	341-348
Number of pages	8
ISBN (Electronic)	9781845648923
ISBN (Print)	9781845648923
DOIs	https://doi.org/10.2495/HHME130361
State	Published - 2014
Externally published	Yes
Event	2013 International Conference on Human Health and Medical Engineering, HHME 2013 - Wuhan, China Duration: 7 Dec 2013 → 8 Dec 2013

Publication series

Name	WIT Transactions on Biomedicine and Health
Volume	18
ISSN (Print)	1743-3525

Conference

Conference	2013 International Conference on Human Health and Medical Engineering, HHME 2013
Country/Territory	China
City	Wuhan
Period	7/12/13 → 8/12/13

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gene expression profile
Lung adenocarcinoma
TNM stage

Access to Document

10.2495/HHME130361

Cite this

@inproceedings{69950bfff4614232948ef5f93821ebd9,

title = "Genomewide expression profile analysis in different TNM stages of lung adenocarcinoma",

abstract = "Most of the gene array-based expression studies of lung cancer have ignored the differences in clinical features, for example the Tumor-Node-Metastasis (TNM) stages of the cancer. In this study, we used a 35K Oligo gene array to identify the differentially expressed genes associated with different TNM stages in lung adenocarcinomas, a subtype with increasing incidence in recent years in China. We identified 10 differentially expressed genes among 90 tumor samples of lung adenocarcinoma at various TNM stages (Stage I, II, and IIIA), of which Zimp7, GINS2, and NAG-1 genes were first reported to be present at a high level in lung adenocarcinoma, and these three genes were confirmed by real-time RT-PCR in a different set of samples. These 10 candidate genes associated with different TNM stages in lung adenocarcinoma in the Chinese population may offer new targets for the diagnosis, therapy, and prognosis prediction of lung adenocarcinoma.",

keywords = "Gene expression profile, Lung adenocarcinoma, TNM stage",

author = "Xiaoli Zhang and Hong Pan and Feng Zhang and Yongbiao Zhang and Yang Zhang and Han Xia and Jing Zhu and Weiling Fu and Ming Liu",

year = "2014",

doi = "10.2495/HHME130361",

language = "英语",

isbn = "9781845648923",

series = "WIT Transactions on Biomedicine and Health",

publisher = "WITPress",

pages = "341--348",

editor = "Zhenyu Du and Maozhu Jin",

booktitle = "Human Health and Medical Engineering",

address = "英国",

note = "2013 International Conference on Human Health and Medical Engineering, HHME 2013 ; Conference date: 07-12-2013 Through 08-12-2013",

}

Zhang, X, Pan, H, Zhang, F, Zhang, Y, Zhang, Y, Xia, H, Zhu, J, Fu, W & Liu, M 2014, Genomewide expression profile analysis in different TNM stages of lung adenocarcinoma. in Z Du & M Jin (eds), Human Health and Medical Engineering. WIT Transactions on Biomedicine and Health, vol. 18, WITPress, pp. 341-348, 2013 International Conference on Human Health and Medical Engineering, HHME 2013, Wuhan, China, 7/12/13. https://doi.org/10.2495/HHME130361

Genomewide expression profile analysis in different TNM stages of lung adenocarcinoma. / Zhang, Xiaoli; Pan, Hong; Zhang, Feng et al.
Human Health and Medical Engineering. ed. / Zhenyu Du; Maozhu Jin. WITPress, 2014. p. 341-348 (WIT Transactions on Biomedicine and Health; Vol. 18).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Genomewide expression profile analysis in different TNM stages of lung adenocarcinoma

AU - Zhang, Xiaoli

AU - Pan, Hong

AU - Zhang, Feng

AU - Zhang, Yongbiao

AU - Zhang, Yang

AU - Xia, Han

AU - Zhu, Jing

AU - Fu, Weiling

AU - Liu, Ming

PY - 2014

Y1 - 2014

N2 - Most of the gene array-based expression studies of lung cancer have ignored the differences in clinical features, for example the Tumor-Node-Metastasis (TNM) stages of the cancer. In this study, we used a 35K Oligo gene array to identify the differentially expressed genes associated with different TNM stages in lung adenocarcinomas, a subtype with increasing incidence in recent years in China. We identified 10 differentially expressed genes among 90 tumor samples of lung adenocarcinoma at various TNM stages (Stage I, II, and IIIA), of which Zimp7, GINS2, and NAG-1 genes were first reported to be present at a high level in lung adenocarcinoma, and these three genes were confirmed by real-time RT-PCR in a different set of samples. These 10 candidate genes associated with different TNM stages in lung adenocarcinoma in the Chinese population may offer new targets for the diagnosis, therapy, and prognosis prediction of lung adenocarcinoma.

AB - Most of the gene array-based expression studies of lung cancer have ignored the differences in clinical features, for example the Tumor-Node-Metastasis (TNM) stages of the cancer. In this study, we used a 35K Oligo gene array to identify the differentially expressed genes associated with different TNM stages in lung adenocarcinomas, a subtype with increasing incidence in recent years in China. We identified 10 differentially expressed genes among 90 tumor samples of lung adenocarcinoma at various TNM stages (Stage I, II, and IIIA), of which Zimp7, GINS2, and NAG-1 genes were first reported to be present at a high level in lung adenocarcinoma, and these three genes were confirmed by real-time RT-PCR in a different set of samples. These 10 candidate genes associated with different TNM stages in lung adenocarcinoma in the Chinese population may offer new targets for the diagnosis, therapy, and prognosis prediction of lung adenocarcinoma.

KW - Gene expression profile

KW - Lung adenocarcinoma

KW - TNM stage

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U2 - 10.2495/HHME130361

DO - 10.2495/HHME130361

M3 - 会议稿件

AN - SCOPUS:84905174591

SN - 9781845648923

T3 - WIT Transactions on Biomedicine and Health

SP - 341

EP - 348

BT - Human Health and Medical Engineering

A2 - Du, Zhenyu

A2 - Jin, Maozhu

PB - WITPress

T2 - 2013 International Conference on Human Health and Medical Engineering, HHME 2013

Y2 - 7 December 2013 through 8 December 2013

ER -

Genomewide expression profile analysis in different TNM stages of lung adenocarcinoma

Abstract

Publication series

Conference

UN SDGs

Keywords

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