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Gene selection through sensitivity analysis of support vector machines

  • Defeng Wang*
  • , Daniel S. Yeung
  • , Eric C.C. Tsang
  • , Lin Shi
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present a novel approach to gene selection for microarry data through the sensitivity analysis of support vector machines (SVMs). A new measurement (sensitivity) is defined to quantify the saliencies of individual features (genes) by analyzing the discriminative function in SVMs. Our feature selection strategy is first to select the features with higher sensitivities but meanwhile keep the remaining ones, and then refine the selected subset by tentatively substituting some part with fragments of the previously rejected features. The accuracy of our method is validated experimentally on the benchmark microarray datasets.

Original languageEnglish
Title of host publicationComputational Life Sciences - First International Symposium, CompLife 2005, Proceedings
PublisherSpringer Verlag
Pages117-127
Number of pages11
ISBN (Print)3540291040, 9783540291046
DOIs
StatePublished - 2005
Externally publishedYes
Event1st International Symposium on Computational Life Sciences, CompLife 2005 - Konstanz, Germany
Duration: 25 Sep 200527 Sep 2005

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3695 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference1st International Symposium on Computational Life Sciences, CompLife 2005
Country/TerritoryGermany
CityKonstanz
Period25/09/0527/09/05

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