FTIR spectroscopic explorations of clinical practice of breast cancer

Xiao Feng Ling; Zhi Xu; Yi Zhuang Xu; Qing Bo Li; Su Zhou; Li Zhang; Hong Mei Zhao; Chun Sheng Hou; Li Xin Wang; Kuan Yong Hou; Xiao Si Zhou; Jin Guang Wu

FTIR spectroscopic explorations of clinical practice of breast cancer

Xiao Feng Ling
, Zhi Xu
, Yi Zhuang Xu^*
, Qing Bo Li
, Su Zhou
, Li Zhang
, Hong Mei Zhao
, Chun Sheng Hou
, Li Xin Wang
, Kuan Yong Hou
, Xiao Si Zhou
, Jin Guang Wu

^*Corresponding author for this work

Peking University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The authors detected ten normal breast tissue samples and eight breast cancer samples by FTIR spectroscopy with an ATR probe. Nineteen variables of thirteen bands in the spectra were compared using standard statistic methods. The results demonstrated that bands of protein, lipid, carbohydrate, and nucleic acid from cancerous samples were significantly different from those from normal ones: (1) The relative intensity of N-H band increased and amide I band shifted to lower wave number significantly; (2) Symmetric and antisymmetric vibrations of -CH₂ group, O=O vibration, and relative intensity of (-CH₂)_n decreased; (3) The intensity of 1160 cm^-1 band was much weaker than that of 1120 cm^-1; (4) The band of P=O or P-O-C shifted toward lower wave number. The authors believe that FTIR spectroscopy has a promising future in breast cancer diagnosis.

Original language	English
Pages (from-to)	198-200
Number of pages	3
Journal	Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis
Volume	25
Issue number	2
State	Published - Feb 2005
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Clinical application exploration
FTIR

Cite this

@article{eee12332952842da93e057641c1359f2,

title = "FTIR spectroscopic explorations of clinical practice of breast cancer",

abstract = "The authors detected ten normal breast tissue samples and eight breast cancer samples by FTIR spectroscopy with an ATR probe. Nineteen variables of thirteen bands in the spectra were compared using standard statistic methods. The results demonstrated that bands of protein, lipid, carbohydrate, and nucleic acid from cancerous samples were significantly different from those from normal ones: (1) The relative intensity of N-H band increased and amide I band shifted to lower wave number significantly; (2) Symmetric and antisymmetric vibrations of -CH2 group, O=O vibration, and relative intensity of (-CH2)n decreased; (3) The intensity of 1160 cm-1 band was much weaker than that of 1120 cm-1; (4) The band of P=O or P-O-C shifted toward lower wave number. The authors believe that FTIR spectroscopy has a promising future in breast cancer diagnosis.",

keywords = "Breast cancer, Clinical application exploration, FTIR",

author = "Ling, \{Xiao Feng\} and Zhi Xu and Xu, \{Yi Zhuang\} and Li, \{Qing Bo\} and Su Zhou and Li Zhang and Zhao, \{Hong Mei\} and Hou, \{Chun Sheng\} and Wang, \{Li Xin\} and Hou, \{Kuan Yong\} and Zhou, \{Xiao Si\} and Wu, \{Jin Guang\}",

year = "2005",

month = feb,

language = "英语",

volume = "25",

pages = "198--200",

journal = "Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis",

issn = "1000-0593",

publisher = "Editorial Office of Spectroscopy and Spectral Analysis",

number = "2",

}

TY - JOUR

T1 - FTIR spectroscopic explorations of clinical practice of breast cancer

AU - Ling, Xiao Feng

AU - Xu, Zhi

AU - Xu, Yi Zhuang

AU - Li, Qing Bo

AU - Zhou, Su

AU - Zhang, Li

AU - Zhao, Hong Mei

AU - Hou, Chun Sheng

AU - Wang, Li Xin

AU - Hou, Kuan Yong

AU - Zhou, Xiao Si

AU - Wu, Jin Guang

PY - 2005/2

Y1 - 2005/2

N2 - The authors detected ten normal breast tissue samples and eight breast cancer samples by FTIR spectroscopy with an ATR probe. Nineteen variables of thirteen bands in the spectra were compared using standard statistic methods. The results demonstrated that bands of protein, lipid, carbohydrate, and nucleic acid from cancerous samples were significantly different from those from normal ones: (1) The relative intensity of N-H band increased and amide I band shifted to lower wave number significantly; (2) Symmetric and antisymmetric vibrations of -CH2 group, O=O vibration, and relative intensity of (-CH2)n decreased; (3) The intensity of 1160 cm-1 band was much weaker than that of 1120 cm-1; (4) The band of P=O or P-O-C shifted toward lower wave number. The authors believe that FTIR spectroscopy has a promising future in breast cancer diagnosis.

AB - The authors detected ten normal breast tissue samples and eight breast cancer samples by FTIR spectroscopy with an ATR probe. Nineteen variables of thirteen bands in the spectra were compared using standard statistic methods. The results demonstrated that bands of protein, lipid, carbohydrate, and nucleic acid from cancerous samples were significantly different from those from normal ones: (1) The relative intensity of N-H band increased and amide I band shifted to lower wave number significantly; (2) Symmetric and antisymmetric vibrations of -CH2 group, O=O vibration, and relative intensity of (-CH2)n decreased; (3) The intensity of 1160 cm-1 band was much weaker than that of 1120 cm-1; (4) The band of P=O or P-O-C shifted toward lower wave number. The authors believe that FTIR spectroscopy has a promising future in breast cancer diagnosis.

KW - Breast cancer

KW - Clinical application exploration

KW - FTIR

UR - https://www.scopus.com/pages/publications/15044362221

M3 - 文章

C2 - 15852855

AN - SCOPUS:15044362221

SN - 1000-0593

VL - 25

SP - 198

EP - 200

JO - Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis

JF - Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis

IS - 2

ER -

FTIR spectroscopic explorations of clinical practice of breast cancer

Abstract

UN SDGs

Keywords

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