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Force unfolding single RNAs: From equilibrium to far-from equilibrium

  • Fei Liu*
  • , Huan Tong
  • , Zhong Can Ou-Yang
  • *Corresponding author for this work
  • Tsinghua University
  • Chinese Academy of Sciences

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We summarize our recent simulation progress of micromanipulation experiments on RNAs. We mainly consults with two important small RNAs unfolding experiments carried out by Bustamante group. Our results show that, in contrast to protein cases, using the single polymer elastic theory and the well-known RNA secondary structure free energy knowledge, we can successively simulate various behaviors of force unfolding RNAs under different experimental setups from equilibrium to far-from equilibrium.

Original languageEnglish
Title of host publicationIUTAM Symposium on Mechanical Behavior and Micro-Mechanics of Nanostructured Materials - Proceedings of the IUTAM Symposium
PublisherSpringer Verlag
Pages95-104
Number of pages10
ISBN (Print)1402056230, 9781402056239
DOIs
StatePublished - 2007
Externally publishedYes
EventIUTAM Symposium on Mechanical Behavior and Micro-Mechanics of Nanostructured Materials - Beijing, China
Duration: 27 Jun 200530 Jun 2005

Publication series

NameSolid Mechanics and its Applications
Volume144
ISSN (Print)1875-3507

Conference

ConferenceIUTAM Symposium on Mechanical Behavior and Micro-Mechanics of Nanostructured Materials
Country/TerritoryChina
CityBeijing
Period27/06/0530/06/05

Keywords

  • Continuous time Monte Carlo method
  • Jarzynski's equality
  • RNA
  • Single-molecule manipulation

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