Flexible Transient Bioelectronic System Enables Multifunctional Active-Controlled Drug Delivery

On-demand drug delivery systems (DDSs) have tremendous promise for clinical in vivo personalized drug delivery. However, the current DDSs are monofunctional and unable to meet the individualized needs of patients. Herein, a biodegradable multifunctional active-controlled drug delivery system (ADDS) is reported. The device can be implanted in various tissues with valves controlled by the deactivation of magnesium (Mg) for rapid drug release from drug reservoirs and long-term drug delivery with the biodegradation of the ADDS. Multiple chambers are constructed by designing a structure with tandem Mg valves and aligning them in the z-axis direction, allowing the system to deliver drugs in a pulsatile or sequential manner. The biodegradability of the entire system minimizes the potential side effects of the ADDS. The application of the device for drug delivery in rats confirmed its ability to perform pulsatile delivery in vivo. The excellent biocompatibility and dual timeline drug delivery capability of this system are demonstrated with cellular and in vitro vascular bioreactors. This multifunctional ADDS will play an important role in precise drug delivery in the treatment of chronic diseases and diseases with complications.