Fabrication of An Immunostimulatory Supramolecular Nanomedicine for Potent Cancer Chemoimmunotherapy

Xinyang Yu; Shaolong Qi; Fangfang Cao; Kai Yang; Hongjian Li; Kun Peng; Zhida Liu; Bing Bai; Marija Buljan; Xiaoyuan Chen; Guocan Yu

doi:10.1021/jacsau.3c00515

Fabrication of An Immunostimulatory Supramolecular Nanomedicine for Potent Cancer Chemoimmunotherapy

Xinyang Yu
, Shaolong Qi
, Fangfang Cao
, Kai Yang
, Hongjian Li
, Kun Peng
, Zhida Liu^*
, Bing Bai
, Marija Buljan^*
, Xiaoyuan Chen^*
, Guocan Yu^*

^*Corresponding author for this work

Tsinghua University
National University of Singapore
Shanxi Academy of Advanced Research and Innovation
Swiss Federal Laboratories for Materials Science and Technology (Empa)

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Chemoimmunotherapy can boost strong antitumor immune responses by triggering immunogenic cell death (ICD), which highlights a promising prospect in clinical applications. However, current chemoimmunotherapy shows limited efficacy due to the low delivery efficiency and insufficient immunogenicity of available chemotherapeutic drugs. A supramolecular polymeric nanomedicine (Pt-Tu@NP) is herein reported using cucurbit[7]uril-based host-guest recognition and noncovalent self-assembly. Pt-Tu@NPs have excellent biodistribution and strongly evoke the endoplasmic reticulum stress-mediated ICD of tumor cells, triggering potent antitumor immune responses by promoting dendritic cell (DC) maturation and cytotoxic T cell infiltration. The coordinated butyrate promotes a positive feedback regulation between DCs and CD8⁺ T cells. Pt-Tu@NPs stimulate immune cold tumors into hot ones, working in synergy with an immune checkpoint blockade to effectively suppress tumor growth and metastasis, which suggests a promising approach for cancer chemoimmunotherapy.

Original language	English
Pages (from-to)	3181-3193
Number of pages	13
Journal	JACS Au
Volume	3
Issue number	11
DOIs	https://doi.org/10.1021/jacsau.3c00515
State	Published - 27 Nov 2023
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer immunotherapy
endoplasmic reticulum stress
host−guest chemistry
immunogenic cell death
supramolecular nanomedicine

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10.1021/jacsau.3c00515

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title = "Fabrication of An Immunostimulatory Supramolecular Nanomedicine for Potent Cancer Chemoimmunotherapy",

abstract = "Chemoimmunotherapy can boost strong antitumor immune responses by triggering immunogenic cell death (ICD), which highlights a promising prospect in clinical applications. However, current chemoimmunotherapy shows limited efficacy due to the low delivery efficiency and insufficient immunogenicity of available chemotherapeutic drugs. A supramolecular polymeric nanomedicine (Pt-Tu@NP) is herein reported using cucurbit[7]uril-based host-guest recognition and noncovalent self-assembly. Pt-Tu@NPs have excellent biodistribution and strongly evoke the endoplasmic reticulum stress-mediated ICD of tumor cells, triggering potent antitumor immune responses by promoting dendritic cell (DC) maturation and cytotoxic T cell infiltration. The coordinated butyrate promotes a positive feedback regulation between DCs and CD8+ T cells. Pt-Tu@NPs stimulate immune cold tumors into hot ones, working in synergy with an immune checkpoint blockade to effectively suppress tumor growth and metastasis, which suggests a promising approach for cancer chemoimmunotherapy.",

keywords = "cancer immunotherapy, endoplasmic reticulum stress, host−guest chemistry, immunogenic cell death, supramolecular nanomedicine",

author = "Xinyang Yu and Shaolong Qi and Fangfang Cao and Kai Yang and Hongjian Li and Kun Peng and Zhida Liu and Bing Bai and Marija Buljan and Xiaoyuan Chen and Guocan Yu",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Published by American Chemical Society.",

year = "2023",

month = nov,

day = "27",

doi = "10.1021/jacsau.3c00515",

language = "英语",

volume = "3",

pages = "3181--3193",

journal = "JACS Au",

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TY - JOUR

T1 - Fabrication of An Immunostimulatory Supramolecular Nanomedicine for Potent Cancer Chemoimmunotherapy

AU - Yu, Xinyang

AU - Qi, Shaolong

AU - Cao, Fangfang

AU - Yang, Kai

AU - Li, Hongjian

AU - Peng, Kun

AU - Liu, Zhida

AU - Bai, Bing

AU - Buljan, Marija

AU - Chen, Xiaoyuan

AU - Yu, Guocan

PY - 2023/11/27

Y1 - 2023/11/27

N2 - Chemoimmunotherapy can boost strong antitumor immune responses by triggering immunogenic cell death (ICD), which highlights a promising prospect in clinical applications. However, current chemoimmunotherapy shows limited efficacy due to the low delivery efficiency and insufficient immunogenicity of available chemotherapeutic drugs. A supramolecular polymeric nanomedicine (Pt-Tu@NP) is herein reported using cucurbit[7]uril-based host-guest recognition and noncovalent self-assembly. Pt-Tu@NPs have excellent biodistribution and strongly evoke the endoplasmic reticulum stress-mediated ICD of tumor cells, triggering potent antitumor immune responses by promoting dendritic cell (DC) maturation and cytotoxic T cell infiltration. The coordinated butyrate promotes a positive feedback regulation between DCs and CD8+ T cells. Pt-Tu@NPs stimulate immune cold tumors into hot ones, working in synergy with an immune checkpoint blockade to effectively suppress tumor growth and metastasis, which suggests a promising approach for cancer chemoimmunotherapy.

AB - Chemoimmunotherapy can boost strong antitumor immune responses by triggering immunogenic cell death (ICD), which highlights a promising prospect in clinical applications. However, current chemoimmunotherapy shows limited efficacy due to the low delivery efficiency and insufficient immunogenicity of available chemotherapeutic drugs. A supramolecular polymeric nanomedicine (Pt-Tu@NP) is herein reported using cucurbit[7]uril-based host-guest recognition and noncovalent self-assembly. Pt-Tu@NPs have excellent biodistribution and strongly evoke the endoplasmic reticulum stress-mediated ICD of tumor cells, triggering potent antitumor immune responses by promoting dendritic cell (DC) maturation and cytotoxic T cell infiltration. The coordinated butyrate promotes a positive feedback regulation between DCs and CD8+ T cells. Pt-Tu@NPs stimulate immune cold tumors into hot ones, working in synergy with an immune checkpoint blockade to effectively suppress tumor growth and metastasis, which suggests a promising approach for cancer chemoimmunotherapy.

KW - cancer immunotherapy

KW - endoplasmic reticulum stress

KW - host−guest chemistry

KW - immunogenic cell death

KW - supramolecular nanomedicine

UR - https://www.scopus.com/pages/publications/85178153651

U2 - 10.1021/jacsau.3c00515

DO - 10.1021/jacsau.3c00515

M3 - 文章

AN - SCOPUS:85178153651

SN - 2691-3704

VL - 3

SP - 3181

EP - 3193

JO - JACS Au

JF - JACS Au

IS - 11

ER -

Fabrication of An Immunostimulatory Supramolecular Nanomedicine for Potent Cancer Chemoimmunotherapy

Abstract

UN SDGs

Keywords

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