Excitation-induced Delayed Onset of Epileptic Poly-spike and Wave Discharges

Suyu Liu; Qingyun Wang

doi:10.1016/j.piutam.2017.08.020

Excitation-induced Delayed Onset of Epileptic Poly-spike and Wave Discharges

Suyu Liu
, Qingyun Wang^*

^*Corresponding author for this work

School of Aeronautic Science and Engineering

Beihang University

Research output: Contribution to journal › Conference article › peer-review

2 Scopus citations

Abstract

In this paper we employ an improved thalamo-cortical model to uncover the potential generation mechanisms of pS-WD patterns by means of bursting oscillation's analysis approaches in the process of seizures generation at both fast and slow timescales. Interestingly, it is found that the onset of epileptic discharges can be delayed as an increase of excitatory regulating function of the thalamic relay neuronal population on cortical PY. The obtained numerical results show that the initiation of absence seizures arises from the thalamus and the termination of them in the cortex.

Original language	English
Pages (from-to)	154-159
Number of pages	6
Journal	Procedia IUTAM
Volume	22
DOIs	https://doi.org/10.1016/j.piutam.2017.08.020
State	Published - 2017
Event	IUTAM Symposium on Nonlinear and Delayed Dynamics of Mechatronic Systems, IUTAM Symposia 2016 - Nanjing, China Duration: 17 Oct 2016 → 21 Oct 2016

Keywords

Absence epilepsy
Delay onset
Fast/slow analysis
Poly-spike and wave discharges
Transition

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10.1016/j.piutam.2017.08.020

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title = "Excitation-induced Delayed Onset of Epileptic Poly-spike and Wave Discharges",

abstract = "In this paper we employ an improved thalamo-cortical model to uncover the potential generation mechanisms of pS-WD patterns by means of bursting oscillation's analysis approaches in the process of seizures generation at both fast and slow timescales. Interestingly, it is found that the onset of epileptic discharges can be delayed as an increase of excitatory regulating function of the thalamic relay neuronal population on cortical PY. The obtained numerical results show that the initiation of absence seizures arises from the thalamus and the termination of them in the cortex.",

keywords = "Absence epilepsy, Delay onset, Fast/slow analysis, Poly-spike and wave discharges, Transition",

author = "Suyu Liu and Qingyun Wang",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors.; IUTAM Symposium on Nonlinear and Delayed Dynamics of Mechatronic Systems, IUTAM Symposia 2016 ; Conference date: 17-10-2016 Through 21-10-2016",

year = "2017",

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T1 - Excitation-induced Delayed Onset of Epileptic Poly-spike and Wave Discharges

AU - Liu, Suyu

AU - Wang, Qingyun

PY - 2017

Y1 - 2017

N2 - In this paper we employ an improved thalamo-cortical model to uncover the potential generation mechanisms of pS-WD patterns by means of bursting oscillation's analysis approaches in the process of seizures generation at both fast and slow timescales. Interestingly, it is found that the onset of epileptic discharges can be delayed as an increase of excitatory regulating function of the thalamic relay neuronal population on cortical PY. The obtained numerical results show that the initiation of absence seizures arises from the thalamus and the termination of them in the cortex.

AB - In this paper we employ an improved thalamo-cortical model to uncover the potential generation mechanisms of pS-WD patterns by means of bursting oscillation's analysis approaches in the process of seizures generation at both fast and slow timescales. Interestingly, it is found that the onset of epileptic discharges can be delayed as an increase of excitatory regulating function of the thalamic relay neuronal population on cortical PY. The obtained numerical results show that the initiation of absence seizures arises from the thalamus and the termination of them in the cortex.

KW - Absence epilepsy

KW - Delay onset

KW - Fast/slow analysis

KW - Poly-spike and wave discharges

KW - Transition

UR - https://www.scopus.com/pages/publications/85029442774

U2 - 10.1016/j.piutam.2017.08.020

DO - 10.1016/j.piutam.2017.08.020

M3 - 会议文章

AN - SCOPUS:85029442774

SN - 2210-9838

VL - 22

SP - 154

EP - 159

JO - Procedia IUTAM

JF - Procedia IUTAM

T2 - IUTAM Symposium on Nonlinear and Delayed Dynamics of Mechatronic Systems, IUTAM Symposia 2016

Y2 - 17 October 2016 through 21 October 2016

ER -

Excitation-induced Delayed Onset of Epileptic Poly-spike and Wave Discharges

Abstract

Keywords

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