Emerging roles of astrocyte for treatment of focal epilepsy and mechanisms underlying lesion development

This study aims to elucidate astrocyte-mediated regulation of focal epileptic seizures and mechanisms underlying the development of epilepsy. To address this, we propose an improved cortical layer model to investigate the function and therapeutic value of astrocyte in neurological disorders. By analyzing the spatio-temporal characteristics of focal epilepsy seizures and their propagation, we find that high frequency inhibitory stimulation appeared to effectively delay or prevent seizures. In addition, the results suggest that different frequencies of Ca²⁺ oscillation and levels of coupling strengths have substantial effects on focal epilepsy. Based on experimental and clinical research findings, we develop a potential clinical application process for epilepsy development and delineate its implications for the possibility of postoperative epilepsy recurrence.