TY - GEN
T1 - Effects of Pressure- And Volume-controlled Ventilation on Pulmonary Ventilation and Gas Exchange in Obstructive Lung Disease
T2 - 3rd International Conference on Intelligent Medicine and Image Processing, IMIP 2021
AU - Liu, Tianya
AU - Yin, Jilai
AU - Qiao, Huiting
AU - Wang, Yawei
AU - Li, Deyu
AU - Fan, Yubo
N1 - Publisher Copyright:
© 2021 ACM.
PY - 2021/4/23
Y1 - 2021/4/23
N2 - Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world. Its pathophysiological hallmark is expiratory flow limitation. But it's unclear whether pressure-controlled ventilation (PCV) or volume-controlled ventilation (VCV) has a lower risk of barotrauma and which one can provide more adequate gas exchange for the patients. In this study, the effects of PCV and VCV on pulmonary ventilation and gas exchange were compared for COPD patients with expiratory flow limitation by modeling the pulmonary ventilation and the gas exchange during mechanical ventilation. It is found the peak transpulmonary pressure was similar between PCV and VCV, indicating the two modes may have similar risk of barotrauma. The transmural pressure of collapsible airways increased more rapidly at the beginning of inspiration in PCV than in VCV. And the partial pressures of oxygen and carbon dioxide were similar between PCV and VCV. The results suggest that the two modes seem to be equally suited for COPD patients with expiratory flow limitation. But PCV may open collapsed airways earlier.
AB - Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world. Its pathophysiological hallmark is expiratory flow limitation. But it's unclear whether pressure-controlled ventilation (PCV) or volume-controlled ventilation (VCV) has a lower risk of barotrauma and which one can provide more adequate gas exchange for the patients. In this study, the effects of PCV and VCV on pulmonary ventilation and gas exchange were compared for COPD patients with expiratory flow limitation by modeling the pulmonary ventilation and the gas exchange during mechanical ventilation. It is found the peak transpulmonary pressure was similar between PCV and VCV, indicating the two modes may have similar risk of barotrauma. The transmural pressure of collapsible airways increased more rapidly at the beginning of inspiration in PCV than in VCV. And the partial pressures of oxygen and carbon dioxide were similar between PCV and VCV. The results suggest that the two modes seem to be equally suited for COPD patients with expiratory flow limitation. But PCV may open collapsed airways earlier.
KW - Expiratory flow limitation
KW - Mechanical ventilation
KW - Pressure-controlled ventilation
KW - Volume-controlled ventilation
UR - https://www.scopus.com/pages/publications/85116581943
U2 - 10.1145/3468945.3468962
DO - 10.1145/3468945.3468962
M3 - 会议稿件
AN - SCOPUS:85116581943
T3 - ACM International Conference Proceeding Series
SP - 101
EP - 108
BT - IMIP 2021 - Proceedings of 2021 3rd International Conference on Intelligent Medicine and Image Processing
PB - Association for Computing Machinery
Y2 - 23 April 2021 through 26 April 2021
ER -