Effect of filtration flow on platelet adhesion an experimental model study

  • Xiaoyan Deng*
  • , Hongbo Zhang
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A sudden tubular expansion with a semi-permeable wall was constructed from a tubular dialysis membrane to investigate the effect of filtration flow on particle deposition. The results showed that adhesion of particles correlated positively with the filtration rate and inversely with the wall shear rate. In the vortex flow region distal to the expansion, particle adhesion was significantly elevated with a maximum at the reattachment point where the wall shear rate was lowest and particles were constantly carried toward the vessel wall along the curved streamlines. In conclusion, filtration flow has a profound impact on the interaction of blood cells such as platelets with blood vessel walls, and disturbed flow with low wall shear rate can enhance the deposits of platelet thrombi to the vessel wall.

Original languageEnglish
Title of host publicationProceedings of the Second IASTED International Conference on Biomechanics
EditorsM.H. Hamza
Pages90-93
Number of pages4
StatePublished - 2004
Externally publishedYes
EventProceedings of the Second IASTED International Conference on Biomechanics - Honolulu, HI, United States
Duration: 23 Aug 200425 Aug 2004

Publication series

NameProceedings of the Second IASTED International Conference on Biomechanics

Conference

ConferenceProceedings of the Second IASTED International Conference on Biomechanics
Country/TerritoryUnited States
CityHonolulu, HI
Period23/08/0425/08/04

Keywords

  • Filtration flow
  • Flow disturbance
  • Platelets
  • Thrombus

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