Dual-frequency intravascular ultrasound imaging of microbubble contrast agents: Ex vivo and in vivo demonstration

Brooks D. Lindsey; K. Heath Martin; Paul A. Dayton; Jianguo Ma; Zhuochen Wang; Xiaoning Jiang

doi:10.1109/ULTSYM.2015.0044

Dual-frequency intravascular ultrasound imaging of microbubble contrast agents: Ex vivo and in vivo demonstration

Brooks D. Lindsey
, K. Heath Martin
, Paul A. Dayton
, Jianguo Ma
, Zhuochen Wang
, Xiaoning Jiang

University of North Carolina-Chapel Hill and North Carolina State University
North Carolina State University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Scopus citations

Abstract

Development of atherosclerotic plaques and related cardiac events are correlated with increased development of vasa vasorum, however, no currently-available diagnostic imaging method has been demonstrated effective at identifying vulnerable plaques. We present a new intravascular ultrasound (IVUS) imaging method using a dual-frequency transducer to visualize contrast flow in microvessels with high specificity. This method uses a specialized transducer capable of exciting contrast agents at a low frequency (5.5 MHz) and receiving superharmonic echoes at a much higher frequency (37 MHz). This dual-frequency transducer was used to image a cellulose micro-tube external to an ex vivo porcine artery and also using the chorioallantoic membrane of a developing chicken embryo. Using dual-frequency contrast-specific imaging, we were able to resolve vessels of a similar size to those found in vulnerable atherosclerotic plaques with clinically-relevant attenuation. The results of this study suggest contrast-specific intravascular ultrasound imaging for the detection of vulnerable plaques in atherosclerosis may provide additional diagnostic information.

Original language	English
Title of host publication	2015 IEEE International Ultrasonics Symposium, IUS 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479981823
DOIs	https://doi.org/10.1109/ULTSYM.2015.0044
State	Published - 13 Nov 2015
Externally published	Yes
Event	IEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China Duration: 21 Oct 2015 → 24 Oct 2015

Publication series

Name	2015 IEEE International Ultrasonics Symposium, IUS 2015

Conference

Conference	IEEE International Ultrasonics Symposium, IUS 2015
Country/Territory	Taiwan, Province of China
City	Taipei
Period	21/10/15 → 24/10/15

Keywords

high frequency ultrasound
intravascular ultrasound
microbubble
vasa vasorum

Access to Document

10.1109/ULTSYM.2015.0044

Cite this

Lindsey, B. D., Martin, K. H., Dayton, P. A., Ma, J., Wang, Z., & Jiang, X. (2015). Dual-frequency intravascular ultrasound imaging of microbubble contrast agents: Ex vivo and in vivo demonstration. In 2015 IEEE International Ultrasonics Symposium, IUS 2015 Article 7329501 (2015 IEEE International Ultrasonics Symposium, IUS 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ULTSYM.2015.0044

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title = "Dual-frequency intravascular ultrasound imaging of microbubble contrast agents: Ex vivo and in vivo demonstration",

abstract = "Development of atherosclerotic plaques and related cardiac events are correlated with increased development of vasa vasorum, however, no currently-available diagnostic imaging method has been demonstrated effective at identifying vulnerable plaques. We present a new intravascular ultrasound (IVUS) imaging method using a dual-frequency transducer to visualize contrast flow in microvessels with high specificity. This method uses a specialized transducer capable of exciting contrast agents at a low frequency (5.5 MHz) and receiving superharmonic echoes at a much higher frequency (37 MHz). This dual-frequency transducer was used to image a cellulose micro-tube external to an ex vivo porcine artery and also using the chorioallantoic membrane of a developing chicken embryo. Using dual-frequency contrast-specific imaging, we were able to resolve vessels of a similar size to those found in vulnerable atherosclerotic plaques with clinically-relevant attenuation. The results of this study suggest contrast-specific intravascular ultrasound imaging for the detection of vulnerable plaques in atherosclerosis may provide additional diagnostic information.",

keywords = "high frequency ultrasound, intravascular ultrasound, microbubble, vasa vasorum",

author = "Lindsey, \{Brooks D.\} and Martin, \{K. Heath\} and Dayton, \{Paul A.\} and Jianguo Ma and Zhuochen Wang and Xiaoning Jiang",

note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; IEEE International Ultrasonics Symposium, IUS 2015 ; Conference date: 21-10-2015 Through 24-10-2015",

year = "2015",

month = nov,

day = "13",

doi = "10.1109/ULTSYM.2015.0044",

language = "英语",

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Lindsey, BD, Martin, KH, Dayton, PA, Ma, J, Wang, Z & Jiang, X 2015, Dual-frequency intravascular ultrasound imaging of microbubble contrast agents: Ex vivo and in vivo demonstration. in 2015 IEEE International Ultrasonics Symposium, IUS 2015., 7329501, 2015 IEEE International Ultrasonics Symposium, IUS 2015, Institute of Electrical and Electronics Engineers Inc., IEEE International Ultrasonics Symposium, IUS 2015, Taipei, Taiwan, Province of China, 21/10/15. https://doi.org/10.1109/ULTSYM.2015.0044

Dual-frequency intravascular ultrasound imaging of microbubble contrast agents: Ex vivo and in vivo demonstration. / Lindsey, Brooks D.; Martin, K. Heath; Dayton, Paul A. et al.
2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7329501 (2015 IEEE International Ultrasonics Symposium, IUS 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T2 - IEEE International Ultrasonics Symposium, IUS 2015

AU - Lindsey, Brooks D.

AU - Martin, K. Heath

AU - Dayton, Paul A.

AU - Ma, Jianguo

AU - Wang, Zhuochen

AU - Jiang, Xiaoning

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N2 - Development of atherosclerotic plaques and related cardiac events are correlated with increased development of vasa vasorum, however, no currently-available diagnostic imaging method has been demonstrated effective at identifying vulnerable plaques. We present a new intravascular ultrasound (IVUS) imaging method using a dual-frequency transducer to visualize contrast flow in microvessels with high specificity. This method uses a specialized transducer capable of exciting contrast agents at a low frequency (5.5 MHz) and receiving superharmonic echoes at a much higher frequency (37 MHz). This dual-frequency transducer was used to image a cellulose micro-tube external to an ex vivo porcine artery and also using the chorioallantoic membrane of a developing chicken embryo. Using dual-frequency contrast-specific imaging, we were able to resolve vessels of a similar size to those found in vulnerable atherosclerotic plaques with clinically-relevant attenuation. The results of this study suggest contrast-specific intravascular ultrasound imaging for the detection of vulnerable plaques in atherosclerosis may provide additional diagnostic information.

AB - Development of atherosclerotic plaques and related cardiac events are correlated with increased development of vasa vasorum, however, no currently-available diagnostic imaging method has been demonstrated effective at identifying vulnerable plaques. We present a new intravascular ultrasound (IVUS) imaging method using a dual-frequency transducer to visualize contrast flow in microvessels with high specificity. This method uses a specialized transducer capable of exciting contrast agents at a low frequency (5.5 MHz) and receiving superharmonic echoes at a much higher frequency (37 MHz). This dual-frequency transducer was used to image a cellulose micro-tube external to an ex vivo porcine artery and also using the chorioallantoic membrane of a developing chicken embryo. Using dual-frequency contrast-specific imaging, we were able to resolve vessels of a similar size to those found in vulnerable atherosclerotic plaques with clinically-relevant attenuation. The results of this study suggest contrast-specific intravascular ultrasound imaging for the detection of vulnerable plaques in atherosclerosis may provide additional diagnostic information.

KW - high frequency ultrasound

KW - intravascular ultrasound

KW - microbubble

KW - vasa vasorum

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M3 - 会议稿件

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PB - Institute of Electrical and Electronics Engineers Inc.

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Lindsey BD, Martin KH, Dayton PA, Ma J, Wang Z, Jiang X. Dual-frequency intravascular ultrasound imaging of microbubble contrast agents: Ex vivo and in vivo demonstration. In 2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers Inc. 2015. 7329501. (2015 IEEE International Ultrasonics Symposium, IUS 2015). doi: 10.1109/ULTSYM.2015.0044

Dual-frequency intravascular ultrasound imaging of microbubble contrast agents: Ex vivo and in vivo demonstration

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Keywords

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