@inproceedings{e34e63c1c6f24f7c8035200f1cd0d22d,
title = "DRMC: A Generalist Model with Dynamic Routing for Multi-center PET Image Synthesis",
abstract = "Multi-center positron emission tomography (PET) image synthesis aims at recovering low-dose PET images from multiple different centers. The generalizability of existing methods can still be suboptimal for a multi-center study due to domain shifts, which result from non-identical data distribution among centers with different imaging systems/protocols. While some approaches address domain shifts by training specialized models for each center, they are parameter inefficient and do not well exploit the shared knowledge across centers. To address this, we develop a generalist model that shares architecture and parameters across centers to utilize the shared knowledge. However, the generalist model can suffer from the center interference issue, i.e. the gradient directions of different centers can be inconsistent or even opposite owing to the non-identical data distribution. To mitigate such interference, we introduce a novel dynamic routing strategy with cross-layer connections that routes data from different centers to different experts. Experiments show that our generalist model with dynamic routing (DRMC) exhibits excellent generalizability across centers. Code and data are available at: https://github.com/Yaziwel/Multi-Center-PET-Image-Synthesis.",
keywords = "Dynamic Routing, Generalist Model, Multi-Center, Positron Emission Tomography, Synthesis",
author = "Zhiwen Yang and Yang Zhou and Hui Zhang and Bingzheng Wei and Yubo Fan and Yan Xu",
note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.; 26th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2023 ; Conference date: 08-10-2023 Through 12-10-2023",
year = "2023",
doi = "10.1007/978-3-031-43898-1\_4",
language = "英语",
isbn = "9783031438974",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "36--46",
editor = "Hayit Greenspan and Hayit Greenspan and Anant Madabhushi and Parvin Mousavi and Septimiu Salcudean and James Duncan and Tanveer Syeda-Mahmood and Russell Taylor",
booktitle = "Medical Image Computing and Computer Assisted Intervention – MICCAI 2023 - 26th International Conference, Proceedings",
address = "德国",
}