DrAgent: Empowering Large Language Models as Medical Agents for Multi-hop Medical Reasoning

  • Fenglin Liu
  • , Zheng Li*
  • , Hongjian Zhou
  • , Qingyu Yin
  • , Jingfeng Yang
  • , Xin Liu
  • , Zhengyang Wang
  • , Xianfeng Tang
  • , Shiyang Li
  • , Xiang He
  • , Ruijie Wang
  • , Bing Yin
  • , Xiao Gu
  • , Lei Clifton
  • , David Clifton*
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Although large language models (LLMs) have demonstrated outperforming human experts in medical examinations, it remains challenging to adopt LLMs in real-world clinical decision-making that typically involves multi-hop medical reasoning. Common practices include prompting commercial LLMs and fine-tuning LLMs on medical data. However, in the clinical domain, using commercial LLMs raises privacy concerns regarding sensitive patient data. Fine-tuning competitive medical LLMs for different tasks usually requires extensive data and computing resources, which are difficult to acquire, especially in medical institutions with limited infrastructure. We propose DrAgent, which can build LLMs as agents to deliver accurate medical decision-making and reasoning. In implementation, we take a lightweight LLM as the backbone to collaborate with diverse clinical tools. To make efficient use of data, DrAgent introduces recursive curriculum learning to optimize the LLM in an easy-to-hard progression. The results show that our approach achieves competitive performance on diverse datasets.

Original languageEnglish
Title of host publicationEMNLP 2025 - 2025 Conference on Empirical Methods in Natural Language Processing, Findings of EMNLP 2025
EditorsChristos Christodoulopoulos, Tanmoy Chakraborty, Carolyn Rose, Violet Peng
PublisherAssociation for Computational Linguistics (ACL)
Pages15656-15668
Number of pages13
ISBN (Electronic)9798891763357
DOIs
StatePublished - 2025
Externally publishedYes
Event30th Conference on Empirical Methods in Natural Language Processing, EMNLP 2025 - Suzhou, China
Duration: 4 Nov 20259 Nov 2025

Publication series

NameEMNLP 2025 - 2025 Conference on Empirical Methods in Natural Language Processing, Findings of EMNLP 2025

Conference

Conference30th Conference on Empirical Methods in Natural Language Processing, EMNLP 2025
Country/TerritoryChina
CitySuzhou
Period4/11/259/11/25

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