Discovery of susceptibility loci associated with tuberculosis in Han Chinese

Hui Qi; Yong Biao Zhang; Lin Sun; Cheng Chen; Biao Xu; Fang Xu; Jia Wen Liu; Jin Cheng Liu; Chen Chen; Wei Wei Jiao; Chen Shen; Jing Xiao; Jie Qiong Li; Ya Jie Guo; Yong Hong Wang; Qin Jing Li; Qing Qin Yin; Ying Jia Li; Ting Wang; Xing Yun Wang; Ming Liang Gu; Jun Yu; A. Dong Shen

doi:10.1093/hmg/ddx365

Discovery of susceptibility loci associated with tuberculosis in Han Chinese

Hui Qi
, Yong Biao Zhang
, Lin Sun
, Cheng Chen
, Biao Xu
, Fang Xu
, Jia Wen Liu
, Jin Cheng Liu
, Chen Chen
, Wei Wei Jiao
, Chen Shen
, Jing Xiao
, Jie Qiong Li
, Ya Jie Guo
, Yong Hong Wang
, Qin Jing Li
, Qing Qin Yin
, Ying Jia Li
, Ting Wang
, Xing Yun Wang

Ming Liang Gu, Jun Yu, A. Dong Shen^*

^*Corresponding author for this work

Capital Medical University
CAS - Beijing Institute of Genomics
Shenzhen Center for Disease Control and Prevention
Fudan University
Karolinska Institutet
Beijing Geriatric Hospital
Tuberculosis Hospital of Shaanxi Province 710100

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB burden, no TB-related GWAS has been performed in China. Here, we performed the first three-stage GWAS on TB in the Han Chinese population. In the stage 1 (discovery stage), after quality control, 691 388 SNPs present in 972 TB patients and 1537 controls were retained. After replication on an additional 3460 TB patients and 4862 controls (stages 2 and 3), we identified three significant loci associated with TB, the most significant of which was rs4240897 (logistic regression P=1.41×10^-11, odds ratio=0.79). The aforementioned three SNPs were harbored by MFN2, RGS12 and human leukocyte antigen class II beta chain paralogue encoding genes, all of which are candidate immune genes associated with TB. Our findings provide new insight into the genetic background of TB in the Han Chinese population.

Original language	English
Pages (from-to)	4752-4763
Number of pages	12
Journal	Human Molecular Genetics
Volume	26
Issue number	23
DOIs	https://doi.org/10.1093/hmg/ddx365
State	Published - 1 Dec 2017
Externally published	Yes

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SDG 3 Good Health and Well-being

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Qi, H., Zhang, Y. B., Sun, L., Chen, C., Xu, B., Xu, F., Liu, J. W., Liu, J. C., Chen, C., Jiao, W. W., Shen, C., Xiao, J., Li, J. Q., Guo, Y. J., Wang, Y. H., Li, Q. J., Yin, Q. Q., Li, Y. J., Wang, T., ... Shen, A. D. (2017). Discovery of susceptibility loci associated with tuberculosis in Han Chinese. Human Molecular Genetics, 26(23), 4752-4763. https://doi.org/10.1093/hmg/ddx365

@article{59d17647275e439cadf54f4c49176ead,

title = "Discovery of susceptibility loci associated with tuberculosis in Han Chinese",

abstract = "Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB burden, no TB-related GWAS has been performed in China. Here, we performed the first three-stage GWAS on TB in the Han Chinese population. In the stage 1 (discovery stage), after quality control, 691 388 SNPs present in 972 TB patients and 1537 controls were retained. After replication on an additional 3460 TB patients and 4862 controls (stages 2 and 3), we identified three significant loci associated with TB, the most significant of which was rs4240897 (logistic regression P=1.41×10-11, odds ratio=0.79). The aforementioned three SNPs were harbored by MFN2, RGS12 and human leukocyte antigen class II beta chain paralogue encoding genes, all of which are candidate immune genes associated with TB. Our findings provide new insight into the genetic background of TB in the Han Chinese population.",

author = "Hui Qi and Zhang, \{Yong Biao\} and Lin Sun and Cheng Chen and Biao Xu and Fang Xu and Liu, \{Jia Wen\} and Liu, \{Jin Cheng\} and Chen Chen and Jiao, \{Wei Wei\} and Chen Shen and Jing Xiao and Li, \{Jie Qiong\} and Guo, \{Ya Jie\} and Wang, \{Yong Hong\} and Li, \{Qin Jing\} and Yin, \{Qing Qin\} and Li, \{Ying Jia\} and Ting Wang and Wang, \{Xing Yun\} and Gu, \{Ming Liang\} and Jun Yu and Shen, \{A. Dong\}",

year = "2017",

month = dec,

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doi = "10.1093/hmg/ddx365",

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Qi, H, Zhang, YB, Sun, L, Chen, C, Xu, B, Xu, F, Liu, JW, Liu, JC, Chen, C, Jiao, WW, Shen, C, Xiao, J, Li, JQ, Guo, YJ, Wang, YH, Li, QJ, Yin, QQ, Li, YJ, Wang, T, Wang, XY, Gu, ML, Yu, J & Shen, AD 2017, 'Discovery of susceptibility loci associated with tuberculosis in Han Chinese', Human Molecular Genetics, vol. 26, no. 23, pp. 4752-4763. https://doi.org/10.1093/hmg/ddx365

TY - JOUR

T1 - Discovery of susceptibility loci associated with tuberculosis in Han Chinese

AU - Qi, Hui

AU - Zhang, Yong Biao

AU - Sun, Lin

AU - Chen, Cheng

AU - Xu, Biao

AU - Xu, Fang

AU - Liu, Jia Wen

AU - Liu, Jin Cheng

AU - Chen, Chen

AU - Jiao, Wei Wei

AU - Shen, Chen

AU - Xiao, Jing

AU - Li, Jie Qiong

AU - Guo, Ya Jie

AU - Wang, Yong Hong

AU - Li, Qin Jing

AU - Yin, Qing Qin

AU - Li, Ying Jia

AU - Wang, Ting

AU - Wang, Xing Yun

AU - Gu, Ming Liang

AU - Yu, Jun

AU - Shen, A. Dong

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB burden, no TB-related GWAS has been performed in China. Here, we performed the first three-stage GWAS on TB in the Han Chinese population. In the stage 1 (discovery stage), after quality control, 691 388 SNPs present in 972 TB patients and 1537 controls were retained. After replication on an additional 3460 TB patients and 4862 controls (stages 2 and 3), we identified three significant loci associated with TB, the most significant of which was rs4240897 (logistic regression P=1.41×10-11, odds ratio=0.79). The aforementioned three SNPs were harbored by MFN2, RGS12 and human leukocyte antigen class II beta chain paralogue encoding genes, all of which are candidate immune genes associated with TB. Our findings provide new insight into the genetic background of TB in the Han Chinese population.

AB - Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB burden, no TB-related GWAS has been performed in China. Here, we performed the first three-stage GWAS on TB in the Han Chinese population. In the stage 1 (discovery stage), after quality control, 691 388 SNPs present in 972 TB patients and 1537 controls were retained. After replication on an additional 3460 TB patients and 4862 controls (stages 2 and 3), we identified three significant loci associated with TB, the most significant of which was rs4240897 (logistic regression P=1.41×10-11, odds ratio=0.79). The aforementioned three SNPs were harbored by MFN2, RGS12 and human leukocyte antigen class II beta chain paralogue encoding genes, all of which are candidate immune genes associated with TB. Our findings provide new insight into the genetic background of TB in the Han Chinese population.

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DO - 10.1093/hmg/ddx365

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AN - SCOPUS:85042232154

SN - 0964-6906

VL - 26

SP - 4752

EP - 4763

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 23

ER -

Discovery of susceptibility loci associated with tuberculosis in Han Chinese

Abstract

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