Design of new gradient scaffolds based on triply periodic minimal surfaces and study on its mechanical, permeability and tissue differentiation characteristics

Zhiqiang Liu; He Gong; Jiazi Gao; Zhehao Liu; Shanshan Zou; Sujing Tian

doi:10.7507/1001-5515.202102054

Design of new gradient scaffolds based on triply periodic minimal surfaces and study on its mechanical, permeability and tissue differentiation characteristics

Zhiqiang Liu
, He Gong
, Jiazi Gao
, Zhehao Liu
, Shanshan Zou
, Sujing Tian

School of Mechanical and Aerospace Engineering

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

为建立具有良好生物学性能的骨支架结构，本文基于螺旋（G）型、菱形（D）型三周期极小曲面（TPMS），设计了两种新型梯度TPMS支架：双向线性渐变G型（L-G型）支架、D型/G型融合（N-G型）支架，并通过压缩仿真获得了两种支架的结构力学性能参数。然后，本文通过计算流体动力学（CFD）仿真获得了支架内流体的流动性能参数，并由达西定律计算出两种支架的渗透率。基于组织分化理论，本研究预测了两种支架的组织分化面积。研究结果显示，L-G型支架较N-G型支架的承载能力更强，而N-G型支架在渗透率及软骨组织分化面积等生物学性能方面更优。L-G型和N-G型支架的建模过程为骨支架的设计提供了一种新思路，文中的仿真分析也可为支架植入人体后的骨整合预测提供参考。.

Original language	English
Pages (from-to)	960-968
Number of pages	9
Journal	Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering
Volume	38
Issue number	5
DOIs	https://doi.org/10.7507/1001-5515.202102054
State	Published - 25 Oct 2021
Externally published	Yes

Keywords

flow property
gradient triply periodic minimal surfaces scaffold
permeability
structural strength
tissue differentiation

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10.7507/1001-5515.202102054

Cite this

@article{b070cf8e298743ec9db8cd954e433d3e,

title = "Design of new gradient scaffolds based on triply periodic minimal surfaces and study on its mechanical, permeability and tissue differentiation characteristics",

abstract = "为建立具有良好生物学性能的骨支架结构，本文基于螺旋（G）型、菱形（D）型三周期极小曲面（TPMS），设计了两种新型梯度TPMS支架：双向线性渐变G型（L-G型）支架、D型/G型融合（N-G型）支架，并通过压缩仿真获得了两种支架的结构力学性能参数。然后，本文通过计算流体动力学（CFD）仿真获得了支架内流体的流动性能参数，并由达西定律计算出两种支架的渗透率。基于组织分化理论，本研究预测了两种支架的组织分化面积。研究结果显示，L-G型支架较N-G型支架的承载能力更强，而N-G型支架在渗透率及软骨组织分化面积等生物学性能方面更优。L-G型和N-G型支架的建模过程为骨支架的设计提供了一种新思路，文中的仿真分析也可为支架植入人体后的骨整合预测提供参考。.",

keywords = "flow property, gradient triply periodic minimal surfaces scaffold, permeability, structural strength, tissue differentiation",

author = "Zhiqiang Liu and He Gong and Jiazi Gao and Zhehao Liu and Shanshan Zou and Sujing Tian",

year = "2021",

month = oct,

day = "25",

doi = "10.7507/1001-5515.202102054",

language = "英语",

volume = "38",

pages = "960--968",

journal = "Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering",

issn = "1001-5515",

publisher = "West China Hospital, Sichuan Institute of Biomedical Engineering",

number = "5",

}

Design of new gradient scaffolds based on triply periodic minimal surfaces and study on its mechanical, permeability and tissue differentiation characteristics. / Liu, Zhiqiang; Gong, He; Gao, Jiazi et al.
In: Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering, Vol. 38, No. 5, 25.10.2021, p. 960-968.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Design of new gradient scaffolds based on triply periodic minimal surfaces and study on its mechanical, permeability and tissue differentiation characteristics

AU - Liu, Zhiqiang

AU - Gong, He

AU - Gao, Jiazi

AU - Liu, Zhehao

AU - Zou, Shanshan

AU - Tian, Sujing

PY - 2021/10/25

Y1 - 2021/10/25

N2 - 为建立具有良好生物学性能的骨支架结构，本文基于螺旋（G）型、菱形（D）型三周期极小曲面（TPMS），设计了两种新型梯度TPMS支架：双向线性渐变G型（L-G型）支架、D型/G型融合（N-G型）支架，并通过压缩仿真获得了两种支架的结构力学性能参数。然后，本文通过计算流体动力学（CFD）仿真获得了支架内流体的流动性能参数，并由达西定律计算出两种支架的渗透率。基于组织分化理论，本研究预测了两种支架的组织分化面积。研究结果显示，L-G型支架较N-G型支架的承载能力更强，而N-G型支架在渗透率及软骨组织分化面积等生物学性能方面更优。L-G型和N-G型支架的建模过程为骨支架的设计提供了一种新思路，文中的仿真分析也可为支架植入人体后的骨整合预测提供参考。.

AB - 为建立具有良好生物学性能的骨支架结构，本文基于螺旋（G）型、菱形（D）型三周期极小曲面（TPMS），设计了两种新型梯度TPMS支架：双向线性渐变G型（L-G型）支架、D型/G型融合（N-G型）支架，并通过压缩仿真获得了两种支架的结构力学性能参数。然后，本文通过计算流体动力学（CFD）仿真获得了支架内流体的流动性能参数，并由达西定律计算出两种支架的渗透率。基于组织分化理论，本研究预测了两种支架的组织分化面积。研究结果显示，L-G型支架较N-G型支架的承载能力更强，而N-G型支架在渗透率及软骨组织分化面积等生物学性能方面更优。L-G型和N-G型支架的建模过程为骨支架的设计提供了一种新思路，文中的仿真分析也可为支架植入人体后的骨整合预测提供参考。.

KW - flow property

KW - gradient triply periodic minimal surfaces scaffold

KW - permeability

KW - structural strength

KW - tissue differentiation

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U2 - 10.7507/1001-5515.202102054

DO - 10.7507/1001-5515.202102054

M3 - 文章

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AN - SCOPUS:85121187389

SN - 1001-5515

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JO - Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering

JF - Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering

IS - 5

ER -

Design of new gradient scaffolds based on triply periodic minimal surfaces and study on its mechanical, permeability and tissue differentiation characteristics

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Keywords

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