Current research progress on cell membrane decorated macroscopic biomaterials

The cell membranes, derived from natural sources, possesses unique physicochemical properties of phospholipid bilayers and biological functionalities of membrane proteins. This makes it an ideal biomimetic coating to enhance the in vivo circulation and retention time of micro/nanodrug carriers, provide targeted drug delivery effects, and neutralize bacterial toxins. Notably, recent studies have successfully coated various types of cell membranes onto the surfaces of macroscopic materials, such as electrospun fiber scaffolds and decellularized matrices, to promote tissue repair, modulate host responses to foreign materials, and alleviate inflammation. This review comprehensively summarizes the latest research progress in the modification of macroscopic biomaterials with cell membranes. The insights provided aim to serve as a valuable reference for the preparation of cell membrane biomimetic coatings and their applications in the field of tissue repair.