Corrosion of, and cellular responses to Mg-Zn-Ca bulk metallic glasses

Xuenan Gu; Yufeng Zheng; Shengping Zhong; Tingfei Xi; Junqiang Wang; Weihua Wang

doi:10.1016/j.biomaterials.2009.11.015

Corrosion of, and cellular responses to Mg-Zn-Ca bulk metallic glasses

Xuenan Gu
, Yufeng Zheng^*
, Shengping Zhong
, Tingfei Xi
, Junqiang Wang
, Weihua Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

404 Scopus citations

Abstract

Mg-Zn-Ca bulk metallic glass with different compositions (Mg66Zn30Ca4 and Mg70Zn25Ca5) have been prepared for this study and their feasibility as biodegradable metallic materials have been evaluated by the microstructural, surface analysis, mechanical testing, corrosion and cytotoxicity tests. It was found that the Mg66Zn30Ca4 sample presents a more uniform corrosion morphology than as-rolled pure Mg and Mg70Zn25Ca5 samples, with much smaller micro-scale uniformly distributed pores beneath the corrosion product layer. The corrosion products were identified to be Mg(OH)₂ and Zn(OH)₂, and a uniform corrosion mechanism is proposed. Both indirect cytotoxicity and direct cell culture experiments were carried out using L929 and MG63 cell lines. The results show higher cell viabilities for Mg-Zn-Ca extracts than that for as-rolled pure Mg. In addition, L929 and MG63 cells were found to adhere and proliferate on the surface of Mg66Zn30Ca4 sample.

Original language	English
Pages (from-to)	1093-1103
Number of pages	11
Journal	Biomaterials
Volume	31
Issue number	6
DOIs	https://doi.org/10.1016/j.biomaterials.2009.11.015
State	Published - Feb 2010
Externally published	Yes

Keywords

Bulk metallic glass
Corrosion
Cytotoxicity
Magnesium alloy
Mechanical property

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10.1016/j.biomaterials.2009.11.015

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title = "Corrosion of, and cellular responses to Mg-Zn-Ca bulk metallic glasses",

abstract = "Mg-Zn-Ca bulk metallic glass with different compositions (Mg66Zn30Ca4 and Mg70Zn25Ca5) have been prepared for this study and their feasibility as biodegradable metallic materials have been evaluated by the microstructural, surface analysis, mechanical testing, corrosion and cytotoxicity tests. It was found that the Mg66Zn30Ca4 sample presents a more uniform corrosion morphology than as-rolled pure Mg and Mg70Zn25Ca5 samples, with much smaller micro-scale uniformly distributed pores beneath the corrosion product layer. The corrosion products were identified to be Mg(OH)2 and Zn(OH)2, and a uniform corrosion mechanism is proposed. Both indirect cytotoxicity and direct cell culture experiments were carried out using L929 and MG63 cell lines. The results show higher cell viabilities for Mg-Zn-Ca extracts than that for as-rolled pure Mg. In addition, L929 and MG63 cells were found to adhere and proliferate on the surface of Mg66Zn30Ca4 sample.",

keywords = "Bulk metallic glass, Corrosion, Cytotoxicity, Magnesium alloy, Mechanical property",

author = "Xuenan Gu and Yufeng Zheng and Shengping Zhong and Tingfei Xi and Junqiang Wang and Weihua Wang",

year = "2010",

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doi = "10.1016/j.biomaterials.2009.11.015",

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TY - JOUR

T1 - Corrosion of, and cellular responses to Mg-Zn-Ca bulk metallic glasses

AU - Gu, Xuenan

AU - Zheng, Yufeng

AU - Zhong, Shengping

AU - Xi, Tingfei

AU - Wang, Junqiang

AU - Wang, Weihua

PY - 2010/2

Y1 - 2010/2

N2 - Mg-Zn-Ca bulk metallic glass with different compositions (Mg66Zn30Ca4 and Mg70Zn25Ca5) have been prepared for this study and their feasibility as biodegradable metallic materials have been evaluated by the microstructural, surface analysis, mechanical testing, corrosion and cytotoxicity tests. It was found that the Mg66Zn30Ca4 sample presents a more uniform corrosion morphology than as-rolled pure Mg and Mg70Zn25Ca5 samples, with much smaller micro-scale uniformly distributed pores beneath the corrosion product layer. The corrosion products were identified to be Mg(OH)2 and Zn(OH)2, and a uniform corrosion mechanism is proposed. Both indirect cytotoxicity and direct cell culture experiments were carried out using L929 and MG63 cell lines. The results show higher cell viabilities for Mg-Zn-Ca extracts than that for as-rolled pure Mg. In addition, L929 and MG63 cells were found to adhere and proliferate on the surface of Mg66Zn30Ca4 sample.

AB - Mg-Zn-Ca bulk metallic glass with different compositions (Mg66Zn30Ca4 and Mg70Zn25Ca5) have been prepared for this study and their feasibility as biodegradable metallic materials have been evaluated by the microstructural, surface analysis, mechanical testing, corrosion and cytotoxicity tests. It was found that the Mg66Zn30Ca4 sample presents a more uniform corrosion morphology than as-rolled pure Mg and Mg70Zn25Ca5 samples, with much smaller micro-scale uniformly distributed pores beneath the corrosion product layer. The corrosion products were identified to be Mg(OH)2 and Zn(OH)2, and a uniform corrosion mechanism is proposed. Both indirect cytotoxicity and direct cell culture experiments were carried out using L929 and MG63 cell lines. The results show higher cell viabilities for Mg-Zn-Ca extracts than that for as-rolled pure Mg. In addition, L929 and MG63 cells were found to adhere and proliferate on the surface of Mg66Zn30Ca4 sample.

KW - Bulk metallic glass

KW - Corrosion

KW - Cytotoxicity

KW - Magnesium alloy

KW - Mechanical property

UR - https://www.scopus.com/pages/publications/72149132248

U2 - 10.1016/j.biomaterials.2009.11.015

DO - 10.1016/j.biomaterials.2009.11.015

M3 - 文章

C2 - 19939446

AN - SCOPUS:72149132248

SN - 0142-9612

VL - 31

SP - 1093

EP - 1103

JO - Biomaterials

JF - Biomaterials

IS - 6

ER -

Corrosion of, and cellular responses to Mg-Zn-Ca bulk metallic glasses

Abstract

Keywords

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