Concentration of chromium in whole blood and erythrocytes showed different relationships with serum apolipoprotein levels in Cr(VI) exposed subjects

Objective: To explore the effects of hexavalent chromium [Cr(VI)] on apolipoprotein(Apo) metabolism. Methods: One hundred and six long-term Cr(VI) exposed subjects and fifty five non-exposed individuals were recruited. The blood metals, glucose and lipid parameters were measured to evaluate the effects of hexavalent chromium on the apolipoproteins. Results: The quantity and homeostasis of multi-elements were significantly different between Cr(VI)exposed subjects and the controls(P < 0.05). The levels of serum TG, FPG, LDL-C, Apo AI, AII, CII, CIII, E and Lp(a) also changed significantly (P < 0.05). Concentration of chromium in whole blood and erythrocytes had different relationships with serum apolipoprotein levels in Cr(VI)exposed subjects. Conclusions: Exposure of hexavalent chromium could significantly change the homeostasis of multi-elements as well as the levels of serum apolipoproteins. Cr(III) and Cr(VI)may have different effects on the apolipoproteins.