BKCa通道的力敏感性

Qingmao Yang; Xiaoling Jia

doi:10.16156/j.1004-7220.2018.02.015

BKCa通道的力敏感性

Translated title of the contribution: The Mechanosensitivity of BKCa Channel

Qingmao Yang
, Xiaoling Jia^*

^*Corresponding author for this work

School of Biological Science and Medical Engineering

Beihang University

Research output: Contribution to journal › Article › peer-review

Abstract

Large-conductance Ca2+-activated K+ (BKCa) channels, activated by stress, exhibit mechanosensitivity and are involved in stress-regulated cellular function. For different types of cells, they will have different expression and activity changes due to their BKCa channels responding to different stress patterns. Correspondingly, the mechanism underling channel activation behaves differently, which is activated by the elevation in Ca2+ concentration or changes in membrane bilayer and cytoskeleton. In this review, the research progress in mechanosensitivity of BKCachannels was summarized from 3 aspects, including its molecular structure basis, manifestation and stress activation mechanism.

Translated title of the contribution	The Mechanosensitivity of BKCa Channel
Original language	Chinese (Traditional)
Pages (from-to)	181-185
Number of pages	5
Journal	Yiyong Shengwu Lixue/Journal of Medical Biomechanics
Volume	33
Issue number	2
DOIs	https://doi.org/10.16156/j.1004-7220.2018.02.015
State	Published - 1 Apr 2018

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title = "BKCa通道的力敏感性",

abstract = "Large-conductance Ca2+-activated K+ (BKCa) channels, activated by stress, exhibit mechanosensitivity and are involved in stress-regulated cellular function. For different types of cells, they will have different expression and activity changes due to their BKCa channels responding to different stress patterns. Correspondingly, the mechanism underling channel activation behaves differently, which is activated by the elevation in Ca2+ concentration or changes in membrane bilayer and cytoskeleton. In this review, the research progress in mechanosensitivity of BKCachannels was summarized from 3 aspects, including its molecular structure basis, manifestation and stress activation mechanism.",

keywords = "BKCa channel, Mechanosensitivity, Stress",

author = "Qingmao Yang and Xiaoling Jia",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 by the Editorial Board of Journal of Medical Biomechanics.",

year = "2018",

month = apr,

day = "1",

doi = "10.16156/j.1004-7220.2018.02.015",

language = "繁体中文",

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TY - JOUR

T1 - BKCa通道的力敏感性

AU - Yang, Qingmao

AU - Jia, Xiaoling

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Large-conductance Ca2+-activated K+ (BKCa) channels, activated by stress, exhibit mechanosensitivity and are involved in stress-regulated cellular function. For different types of cells, they will have different expression and activity changes due to their BKCa channels responding to different stress patterns. Correspondingly, the mechanism underling channel activation behaves differently, which is activated by the elevation in Ca2+ concentration or changes in membrane bilayer and cytoskeleton. In this review, the research progress in mechanosensitivity of BKCachannels was summarized from 3 aspects, including its molecular structure basis, manifestation and stress activation mechanism.

AB - Large-conductance Ca2+-activated K+ (BKCa) channels, activated by stress, exhibit mechanosensitivity and are involved in stress-regulated cellular function. For different types of cells, they will have different expression and activity changes due to their BKCa channels responding to different stress patterns. Correspondingly, the mechanism underling channel activation behaves differently, which is activated by the elevation in Ca2+ concentration or changes in membrane bilayer and cytoskeleton. In this review, the research progress in mechanosensitivity of BKCachannels was summarized from 3 aspects, including its molecular structure basis, manifestation and stress activation mechanism.

KW - BKCa channel

KW - Mechanosensitivity

KW - Stress

UR - https://www.scopus.com/pages/publications/85061381718

U2 - 10.16156/j.1004-7220.2018.02.015

DO - 10.16156/j.1004-7220.2018.02.015

M3 - 文章

AN - SCOPUS:85061381718

SN - 1004-7220

VL - 33

SP - 181

EP - 185

JO - Yiyong Shengwu Lixue/Journal of Medical Biomechanics

JF - Yiyong Shengwu Lixue/Journal of Medical Biomechanics

IS - 2

ER -

BKCa通道的力敏感性

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