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Biocompatibility of chitosan/heparin multilayer coating on NiTi alloy

  • Ping Dong
  • , Lingwei Yuan
  • , Weichang Hao*
  • , Yayi Xia
  • , Guozu Da
  • , Tianmin Wang
  • *Corresponding author for this work
  • Beihang University
  • Lanzhou University
  • Seemine Company

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Nickel Titanium alloy has been used widely in clinical iatrology for years because of its unique shape memory capability, proper elasticity and considerable biocompatibility. But as an implanted material, its possible release of Ni ions which might cause toxic effect and its improvable biocompatibility draw attentions of researchers. In this study, chitosan/heparin multilayer is coated on NiTi shape memory alloy by electrostatic self-assemble method. Field emission scanning electron microscopy (FE-SEM), contact angle test is used to show its surface character; hemolysis test, dynamic clotting time experiment and platelet binding test are utilized to investigate the blood compatibility of the materials. The results reveal that the hydrophilic character of the coated one is better than the substrate, and blood compatibility of NiTi is improved by coating treatment.

Original languageEnglish
Title of host publicationMaterials Research
EditorsZhongwei Gu, Zhongwei Gu, Zhongwei Gu, Yafang Han, Yafang Han, Yafang Han, Fusheng Pan, Fusheng Pan, Fusheng Pan, Fusheng Pan, Fusheng Pan, Fusheng Pan, Xitao Wang, Xitao Wang, Xitao Wang, Duan Weng, Duan Weng, Duan Weng, Shaoxiong Zhou, Shaoxiong Zhou, Shaoxiong Zhou
PublisherTrans Tech Publications Ltd
Pages1179-1182
Number of pages4
ISBN (Print)9780878493401, 9780878493401, 9780878493401
DOIs
StatePublished - 2009
EventMRS International Materials Research Conference, IMRC 2008 - Chongqing, China
Duration: 9 Jun 200812 Jun 2008

Publication series

NameMaterials Science Forum
Volume610-613
ISSN (Print)0255-5476
ISSN (Electronic)1662-9752

Conference

ConferenceMRS International Materials Research Conference, IMRC 2008
Country/TerritoryChina
CityChongqing
Period9/06/0812/06/08

Keywords

  • Biocompatibility
  • Chitosan/heparin
  • Electrostatic self-assemble
  • NiTi

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