Availability of floating-reference theory to non-invasive blood component measurement by optical technology

Based on the studies of floating-reference theory (FRT) applied to non-invasive optical blood glucose sensing, this paper further investigated the availability of FRT in measuring other blood components, like bilirubin. According to the conditions of the radial reference location, the results of Monte Carlo simulation show no appearance of radial reference location in non-invasive bilirubin measurement. While the study on the replacement effect of bilirubin and water shows that, at the wavelength of 524 nm, the absorption value of bilirubin solution has no relationship with its concentration. Therefore, this wavelength is regarded as the reference wavelength, and in the further study, it can be used to remove the influence caused by the change of environment and background. In general, the application of FRT in blood glucose and bilirubin shows the specificity of floating reference location and floating reference wavelength in measuring different blood components by optical technology within the designated wavelength, which further improves and extends the application of FRT.