Assessing breast tumor margin by multispectral photoacoustic tomography

Rui Li; Pu Wang; Lu Lan; Frank P. Lloyd; Craig J. Goergen; Shaoxiong Chen; Ji Xin Cheng

doi:10.1364/BOE.6.001273

Assessing breast tumor margin by multispectral photoacoustic tomography

Rui Li
, Pu Wang
, Lu Lan
, Frank P. Lloyd
, Craig J. Goergen
, Shaoxiong Chen
, Ji Xin Cheng^*

^*Corresponding author for this work

Purdue University
Surgical Oncology- Cascade Metrix/Putman County Hospital
Indiana University Bloomington

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin assessment using fat and hemoglobin as contrasts. This system provides ~3 mm tissue depth and ~125 μm axial resolution. The results agreed with the histological findings. A high sensitivity in margin assessment was accomplished, which opens a compelling way to intraoperative margin assessment.

Original language	English
Article number	A015
Pages (from-to)	1273-1281
Number of pages	9
Journal	Biomedical Optics Express
Volume	6
Issue number	4
DOIs	https://doi.org/10.1364/BOE.6.001273
State	Published - 12 Mar 2015
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1364/BOE.6.001273

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title = "Assessing breast tumor margin by multispectral photoacoustic tomography",

abstract = "An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin assessment using fat and hemoglobin as contrasts. This system provides \textasciitilde{}3 mm tissue depth and \textasciitilde{}125 μm axial resolution. The results agreed with the histological findings. A high sensitivity in margin assessment was accomplished, which opens a compelling way to intraoperative margin assessment.",

author = "Rui Li and Pu Wang and Lu Lan and Lloyd, \{Frank P.\} and Goergen, \{Craig J.\} and Shaoxiong Chen and Cheng, \{Ji Xin\}",

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year = "2015",

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doi = "10.1364/BOE.6.001273",

language = "英语",

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T1 - Assessing breast tumor margin by multispectral photoacoustic tomography

AU - Li, Rui

AU - Wang, Pu

AU - Lan, Lu

AU - Lloyd, Frank P.

AU - Goergen, Craig J.

AU - Chen, Shaoxiong

AU - Cheng, Ji Xin

PY - 2015/3/12

Y1 - 2015/3/12

N2 - An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin assessment using fat and hemoglobin as contrasts. This system provides ~3 mm tissue depth and ~125 μm axial resolution. The results agreed with the histological findings. A high sensitivity in margin assessment was accomplished, which opens a compelling way to intraoperative margin assessment.

AB - An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin assessment using fat and hemoglobin as contrasts. This system provides ~3 mm tissue depth and ~125 μm axial resolution. The results agreed with the histological findings. A high sensitivity in margin assessment was accomplished, which opens a compelling way to intraoperative margin assessment.

UR - https://www.scopus.com/pages/publications/84941961028

U2 - 10.1364/BOE.6.001273

DO - 10.1364/BOE.6.001273

M3 - 文章

AN - SCOPUS:84941961028

SN - 2156-7085

VL - 6

SP - 1273

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JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 4

M1 - A015

ER -

Assessing breast tumor margin by multispectral photoacoustic tomography

Abstract

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