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An analytic reflection method for time-domain fluorescence diffuse optical tomography based on a generalized pulse spectrum technique

  • Huiyuan He*
  • , Limin Zhang
  • , Feng Gao
  • , Zheng Ma
  • , Huijian Zhao
  • , Jingying Jiang
  • *Corresponding author for this work
  • Tianjin University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

An image reconstruction scheme for time-domain fluorescence diffuse optical tomography is proposed using a reflection-mode for a semi-infinite turbid geometry. The method is based on a generalized pulse spectrum technique that employs analytic expressions of the Laplace-transformed time-domain photon-diffusion model to construct a Born normalized inverse model, and a pair of real domain transform-factors to separate distributions of the fluorescent yield and lifetime. The methodology is validated with a specifically-developed fluorescent Monte-Carlo simulator or finite-element-based methods and its robustness to the background uncertainties is investigated.

Original languageEnglish
Title of host publicationMultimodal Biomedical Imaging III
DOIs
StatePublished - 2008
Externally publishedYes
EventMultimodal Biomedical Imaging III - San Jose, CA, United States
Duration: 19 Jan 200821 Jan 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6850
ISSN (Print)1605-7422

Conference

ConferenceMultimodal Biomedical Imaging III
Country/TerritoryUnited States
CitySan Jose, CA
Period19/01/0821/01/08

Keywords

  • Analytic solution of the diffuse equation
  • Born approach
  • Finite-element-based methods
  • Fluorescence molecular tomography
  • Generalized pulse spectrum technique

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