A wearable electrostimulation platform enables a universal strategy for on-demand drug delivery

External electric fields, particularly iontophoresis, are promising in delivering anesthetics, anti-inflammatory agents, and anticancer agents by modulating cellular behavior and drug transport. However, current electrically controlled delivery systems face barriers of slow transdermal rates and insufficient penetration depth, restricting their utility for sustained, high-dose, deep-tissue drug delivery in chronic disease treatment. This preview highlights an innovative portable electrostimulation system that integrates electroresponsive hydrogel and microneedle arrays into a wearable transdermal device to enable programmable, long-acting, and on-demand drug delivery. It significantly enhances the transdermal delivery of macromolecules including insulin/glucagon and anti-tumor drug, and it holds future potential for integration with flexible electronics and cellular electrostimulation, opening new avenues for universal drug delivery platforms to advance next-generation disease therapeutics.