A tough graphene nanosheet/hydroxyapatite composite with improved in vitro biocompatibility

Lv Zhang; Weiwei Liu; Chunguang Yue; Taihua Zhang; Pei Li; Zhanwen Xing; Yao Chen

doi:10.1016/j.carbon.2013.04.074

A tough graphene nanosheet/hydroxyapatite composite with improved in vitro biocompatibility

Lv Zhang
, Weiwei Liu
, Chunguang Yue
, Taihua Zhang
, Pei Li
, Zhanwen Xing
, Yao Chen^*

^*Corresponding author for this work

Soochow University
CAS - Institute of Mechanics

Research output: Contribution to journal › Article › peer-review

257 Scopus citations

Abstract

Mechanical properties and in vitro biocompatibility of graphene/ hydroxyapatite (HA) composite synthesized using spark plasma sintering (SPS) are reported in this study. Raman spectroscopy corroborated that graphene nanosheets (GNSs) survived the harsh processing conditions of the selected SPS processing parameters. A 1.0 wt.% GNS/HA composite exhibits ∼80% improvement in fracture toughness as compared to pure HA. GNS pull-out, grain bridging by GNS, crack bridging and crack deflection are the major toughening mechanisms that resist crack propagation. In vitro osteoblast growth tests illustrate that the added GNSs contribute to the improvement of both osteoblast adhesion and apatite mineralization. Therefore, the GNS/HA composite is expected to be a promising material for load-bearing orthopedic implants.

Original language	English
Pages (from-to)	105-115
Number of pages	11
Journal	Carbon
Volume	61
DOIs	https://doi.org/10.1016/j.carbon.2013.04.074
State	Published - Sep 2013
Externally published	Yes

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10.1016/j.carbon.2013.04.074

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title = "A tough graphene nanosheet/hydroxyapatite composite with improved in vitro biocompatibility",

abstract = "Mechanical properties and in vitro biocompatibility of graphene/ hydroxyapatite (HA) composite synthesized using spark plasma sintering (SPS) are reported in this study. Raman spectroscopy corroborated that graphene nanosheets (GNSs) survived the harsh processing conditions of the selected SPS processing parameters. A 1.0 wt.\% GNS/HA composite exhibits ∼80\% improvement in fracture toughness as compared to pure HA. GNS pull-out, grain bridging by GNS, crack bridging and crack deflection are the major toughening mechanisms that resist crack propagation. In vitro osteoblast growth tests illustrate that the added GNSs contribute to the improvement of both osteoblast adhesion and apatite mineralization. Therefore, the GNS/HA composite is expected to be a promising material for load-bearing orthopedic implants.",

author = "Lv Zhang and Weiwei Liu and Chunguang Yue and Taihua Zhang and Pei Li and Zhanwen Xing and Yao Chen",

year = "2013",

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doi = "10.1016/j.carbon.2013.04.074",

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T1 - A tough graphene nanosheet/hydroxyapatite composite with improved in vitro biocompatibility

AU - Zhang, Lv

AU - Liu, Weiwei

AU - Yue, Chunguang

AU - Zhang, Taihua

AU - Li, Pei

AU - Xing, Zhanwen

AU - Chen, Yao

PY - 2013/9

Y1 - 2013/9

N2 - Mechanical properties and in vitro biocompatibility of graphene/ hydroxyapatite (HA) composite synthesized using spark plasma sintering (SPS) are reported in this study. Raman spectroscopy corroborated that graphene nanosheets (GNSs) survived the harsh processing conditions of the selected SPS processing parameters. A 1.0 wt.% GNS/HA composite exhibits ∼80% improvement in fracture toughness as compared to pure HA. GNS pull-out, grain bridging by GNS, crack bridging and crack deflection are the major toughening mechanisms that resist crack propagation. In vitro osteoblast growth tests illustrate that the added GNSs contribute to the improvement of both osteoblast adhesion and apatite mineralization. Therefore, the GNS/HA composite is expected to be a promising material for load-bearing orthopedic implants.

AB - Mechanical properties and in vitro biocompatibility of graphene/ hydroxyapatite (HA) composite synthesized using spark plasma sintering (SPS) are reported in this study. Raman spectroscopy corroborated that graphene nanosheets (GNSs) survived the harsh processing conditions of the selected SPS processing parameters. A 1.0 wt.% GNS/HA composite exhibits ∼80% improvement in fracture toughness as compared to pure HA. GNS pull-out, grain bridging by GNS, crack bridging and crack deflection are the major toughening mechanisms that resist crack propagation. In vitro osteoblast growth tests illustrate that the added GNSs contribute to the improvement of both osteoblast adhesion and apatite mineralization. Therefore, the GNS/HA composite is expected to be a promising material for load-bearing orthopedic implants.

UR - https://www.scopus.com/pages/publications/84879685607

U2 - 10.1016/j.carbon.2013.04.074

DO - 10.1016/j.carbon.2013.04.074

M3 - 文章

AN - SCOPUS:84879685607

SN - 0008-6223

VL - 61

SP - 105

EP - 115

JO - Carbon

JF - Carbon

ER -

A tough graphene nanosheet/hydroxyapatite composite with improved in vitro biocompatibility

Abstract

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