A single ZnO nanofiber-based highly sensitive amperometric glucose biosensor

Mashkoor Ahmad; Caofeng Pan; Zhixiang Luo; Jing Zhu

doi:10.1021/jp102505g

A single ZnO nanofiber-based highly sensitive amperometric glucose biosensor

Mashkoor Ahmad
, Caofeng Pan
, Zhixiang Luo
, Jing Zhu^*

^*Corresponding author for this work

Tsinghua University

Research output: Contribution to journal › Article › peer-review

229 Scopus citations

Abstract

A novel fabrication approach of a highly sensitive amperometric glucose biosensor based on a single ZnO nanofiber (ZONF) is presented. Nanofibers (NFs) of poly(vinyl pyrrolidone)/zinc acetate composite have been synthesized by electrospinning technique. By high-temperature calcinations of the above precursor fibers, ZONFs with diameters in the range of 350-195 nm have been successfully obtained. A single NF on a gold electrode is functionalized with glucose oxidase (GOx) by physical adsorption. Electrochemical measurements of the biosensor revealed a high and reproducible sensitivity of 70.2 μA cm ^-2 mM^-1 within a response time of less than 4 s. The biosensor also showed a linear range from 0.25 to 19 mM with a low limit of detection (LOD) of 1 μM. Furthermore, it has been revealed that the biosensor exhibits a good anti-interference ability and favorable stability over relatively long-term storage (more than 4 months). All these results strongly suggest that a single ZONF can provide a new platform for biosensor design and other biological applications.

Original language	English
Pages (from-to)	9308-9313
Number of pages	6
Journal	Journal of Physical Chemistry C
Volume	114
Issue number	20
DOIs	https://doi.org/10.1021/jp102505g
State	Published - 27 May 2010
Externally published	Yes

Access to Document

10.1021/jp102505g

Cite this

@article{a56e978107d64b9493c2e34cd2017ea6,

title = "A single ZnO nanofiber-based highly sensitive amperometric glucose biosensor",

abstract = "A novel fabrication approach of a highly sensitive amperometric glucose biosensor based on a single ZnO nanofiber (ZONF) is presented. Nanofibers (NFs) of poly(vinyl pyrrolidone)/zinc acetate composite have been synthesized by electrospinning technique. By high-temperature calcinations of the above precursor fibers, ZONFs with diameters in the range of 350-195 nm have been successfully obtained. A single NF on a gold electrode is functionalized with glucose oxidase (GOx) by physical adsorption. Electrochemical measurements of the biosensor revealed a high and reproducible sensitivity of 70.2 μA cm -2 mM-1 within a response time of less than 4 s. The biosensor also showed a linear range from 0.25 to 19 mM with a low limit of detection (LOD) of 1 μM. Furthermore, it has been revealed that the biosensor exhibits a good anti-interference ability and favorable stability over relatively long-term storage (more than 4 months). All these results strongly suggest that a single ZONF can provide a new platform for biosensor design and other biological applications.",

author = "Mashkoor Ahmad and Caofeng Pan and Zhixiang Luo and Jing Zhu",

year = "2010",

month = may,

day = "27",

doi = "10.1021/jp102505g",

language = "英语",

volume = "114",

pages = "9308--9313",

journal = "Journal of Physical Chemistry C",

issn = "1932-7447",

publisher = "American Chemical Society",

number = "20",

}

TY - JOUR

T1 - A single ZnO nanofiber-based highly sensitive amperometric glucose biosensor

AU - Ahmad, Mashkoor

AU - Pan, Caofeng

AU - Luo, Zhixiang

AU - Zhu, Jing

PY - 2010/5/27

Y1 - 2010/5/27

N2 - A novel fabrication approach of a highly sensitive amperometric glucose biosensor based on a single ZnO nanofiber (ZONF) is presented. Nanofibers (NFs) of poly(vinyl pyrrolidone)/zinc acetate composite have been synthesized by electrospinning technique. By high-temperature calcinations of the above precursor fibers, ZONFs with diameters in the range of 350-195 nm have been successfully obtained. A single NF on a gold electrode is functionalized with glucose oxidase (GOx) by physical adsorption. Electrochemical measurements of the biosensor revealed a high and reproducible sensitivity of 70.2 μA cm -2 mM-1 within a response time of less than 4 s. The biosensor also showed a linear range from 0.25 to 19 mM with a low limit of detection (LOD) of 1 μM. Furthermore, it has been revealed that the biosensor exhibits a good anti-interference ability and favorable stability over relatively long-term storage (more than 4 months). All these results strongly suggest that a single ZONF can provide a new platform for biosensor design and other biological applications.

AB - A novel fabrication approach of a highly sensitive amperometric glucose biosensor based on a single ZnO nanofiber (ZONF) is presented. Nanofibers (NFs) of poly(vinyl pyrrolidone)/zinc acetate composite have been synthesized by electrospinning technique. By high-temperature calcinations of the above precursor fibers, ZONFs with diameters in the range of 350-195 nm have been successfully obtained. A single NF on a gold electrode is functionalized with glucose oxidase (GOx) by physical adsorption. Electrochemical measurements of the biosensor revealed a high and reproducible sensitivity of 70.2 μA cm -2 mM-1 within a response time of less than 4 s. The biosensor also showed a linear range from 0.25 to 19 mM with a low limit of detection (LOD) of 1 μM. Furthermore, it has been revealed that the biosensor exhibits a good anti-interference ability and favorable stability over relatively long-term storage (more than 4 months). All these results strongly suggest that a single ZONF can provide a new platform for biosensor design and other biological applications.

UR - https://www.scopus.com/pages/publications/77952692145

U2 - 10.1021/jp102505g

DO - 10.1021/jp102505g

M3 - 文章

AN - SCOPUS:77952692145

SN - 1932-7447

VL - 114

SP - 9308

EP - 9313

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

IS - 20

ER -

A single ZnO nanofiber-based highly sensitive amperometric glucose biosensor

Abstract

Access to Document

Other files and links

Fingerprint

Cite this