A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer

Yanyan Hu; Chongwei Chi; Shunhao Wang; Lingxiong Wang; Ping Liang; Fangyi Liu; Wenting Shang; Weiwei Wang; Fengrong Zhang; Shanshan Li; Heyun Shen; Xiaoling Yu; Huiyu Liu; Jie Tian

doi:10.1002/adma.201700448

A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer

Yanyan Hu
, Chongwei Chi
, Shunhao Wang
, Lingxiong Wang
, Ping Liang
, Fangyi Liu
, Wenting Shang
, Weiwei Wang
, Fengrong Zhang
, Shanshan Li
, Heyun Shen
, Xiaoling Yu^*
, Huiyu Liu
, Jie Tian

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Although nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (¹²⁵I) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients.

Original language	English
Article number	1700448
Journal	Advanced Materials
Volume	29
Issue number	33
DOIs	https://doi.org/10.1002/adma.201700448
State	Published - 6 Sep 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

active targeting
clinical intervention
gold nanoshells
interventional photothermal therapy
pancreatic cancer

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10.1002/adma.201700448

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title = "A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer",

abstract = "Although nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (125I) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25\% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients.",

keywords = "active targeting, clinical intervention, gold nanoshells, interventional photothermal therapy, pancreatic cancer",

author = "Yanyan Hu and Chongwei Chi and Shunhao Wang and Lingxiong Wang and Ping Liang and Fangyi Liu and Wenting Shang and Weiwei Wang and Fengrong Zhang and Shanshan Li and Heyun Shen and Xiaoling Yu and Huiyu Liu and Jie Tian",

note = "Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2017",

month = sep,

day = "6",

doi = "10.1002/adma.201700448",

language = "英语",

volume = "29",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

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T1 - A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer

AU - Hu, Yanyan

AU - Chi, Chongwei

AU - Wang, Shunhao

AU - Wang, Lingxiong

AU - Liang, Ping

AU - Liu, Fangyi

AU - Shang, Wenting

AU - Wang, Weiwei

AU - Zhang, Fengrong

AU - Li, Shanshan

AU - Shen, Heyun

AU - Yu, Xiaoling

AU - Liu, Huiyu

AU - Tian, Jie

PY - 2017/9/6

Y1 - 2017/9/6

N2 - Although nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (125I) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients.

AB - Although nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (125I) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients.

KW - active targeting

KW - clinical intervention

KW - gold nanoshells

KW - interventional photothermal therapy

KW - pancreatic cancer

UR - https://www.scopus.com/pages/publications/85021821747

U2 - 10.1002/adma.201700448

DO - 10.1002/adma.201700448

M3 - 文章

C2 - 28682465

AN - SCOPUS:85021821747

SN - 0935-9648

VL - 29

JO - Advanced Materials

JF - Advanced Materials

IS - 33

M1 - 1700448

ER -

A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer

Abstract

UN SDGs

Keywords

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