A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing

Jun Deng; Yingying Tang; Qing Zhang; Chao Wang; Min Liao; Ping Ji; Jinlin Song; Gaoxing Luo; Luo Chen; Xiaohong Ran; Ziming Wei; Liwen Zheng; Ruyi Dang; Xiang Liu; Hongmei Zhang; Yu Shrike Zhang; Ximu Zhang; Hong Tan

doi:10.1002/adfm.201809110

A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing

Jun Deng
, Yingying Tang
, Qing Zhang
, Chao Wang
, Min Liao
, Ping Ji
, Jinlin Song
, Gaoxing Luo
, Luo Chen
, Xiaohong Ran
, Ziming Wei
, Liwen Zheng
, Ruyi Dang
, Xiang Liu
, Hongmei Zhang^*
, Yu Shrike Zhang
, Ximu Zhang
, Hong Tan

^*Corresponding author for this work

Chongqing Medical University
Children's Hospital of Chongqing Medical University
Brigham and Women’s Hospital
Sichuan University

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD-based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD-based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD-based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.

Original language	English
Article number	1809110
Journal	Advanced Functional Materials
Volume	29
Issue number	31
DOIs	https://doi.org/10.1002/adfm.201809110
State	Published - 1 Aug 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 7 Affordable and Clean Energy

Keywords

Andrias davidianus
Chinese giant salamander
adhesive
hydrogel
wound healing

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10.1002/adfm.201809110

Cite this

Deng, J., Tang, Y., Zhang, Q., Wang, C., Liao, M., Ji, P., Song, J., Luo, G., Chen, L., Ran, X., Wei, Z., Zheng, L., Dang, R., Liu, X., Zhang, H., Zhang, Y. S., Zhang, X., & Tan, H. (2019). A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing. Advanced Functional Materials, 29(31), Article 1809110. https://doi.org/10.1002/adfm.201809110

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title = "A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing",

abstract = "Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD-based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD-based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD-based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.",

keywords = "Andrias davidianus, Chinese giant salamander, adhesive, hydrogel, wound healing",

author = "Jun Deng and Yingying Tang and Qing Zhang and Chao Wang and Min Liao and Ping Ji and Jinlin Song and Gaoxing Luo and Luo Chen and Xiaohong Ran and Ziming Wei and Liwen Zheng and Ruyi Dang and Xiang Liu and Hongmei Zhang and Zhang, \{Yu Shrike\} and Ximu Zhang and Hong Tan",

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year = "2019",

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doi = "10.1002/adfm.201809110",

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T1 - A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing

AU - Deng, Jun

AU - Tang, Yingying

AU - Zhang, Qing

AU - Wang, Chao

AU - Liao, Min

AU - Ji, Ping

AU - Song, Jinlin

AU - Luo, Gaoxing

AU - Chen, Luo

AU - Ran, Xiaohong

AU - Wei, Ziming

AU - Zheng, Liwen

AU - Dang, Ruyi

AU - Liu, Xiang

AU - Zhang, Hongmei

AU - Zhang, Yu Shrike

AU - Zhang, Ximu

AU - Tan, Hong

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD-based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD-based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD-based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.

AB - Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD-based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD-based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD-based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.

KW - Andrias davidianus

KW - Chinese giant salamander

KW - adhesive

KW - hydrogel

KW - wound healing

UR - https://www.scopus.com/pages/publications/85069940243

U2 - 10.1002/adfm.201809110

DO - 10.1002/adfm.201809110

M3 - 文章

AN - SCOPUS:85069940243

SN - 1616-301X

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JO - Advanced Functional Materials

JF - Advanced Functional Materials

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ER -

A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing

Abstract

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Keywords

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